Stathmin

From Proteopedia

Revision as of 08:12, 10 February 2020

spinqualitylabelsall models Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Stathmin-4 (STM-4) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer[1]. Disease Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease[2]. 3D Structures of stathmin-4 Stathmin-4 3D structures

3D Structures of stathmin-4

Updated on 10-February-2020 {{#tree:id=OrganizedByTopic|openlevels=0|

• Stathmin SLD domain complex with tubulin

• • 3ryf – rSTM + tubulin + GTP - rat
    
  • 3hkb, 3ryc, 3ryi – rSTM + tubulin + GTP + GDP
    
  • 3ryh – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate
    
  • 3hkc, 3n2g, 3n2k – rSTM + tubulin + GTP + GDP + pyridine derivative
    
  • 3hkd – rSTM + tubulin + GTP + GDP + pyrrolidine derivative
    
  • 3hke – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative
    
  • 6h9b – rSTM + tubulin + GTP + GDP + quinoline derivative
    

• Stathmin SLD domain complex with tubulin and drugs

• • 1sa0 – rSTM + tubulin + GTP + GDP + anti-gout drug
    
  • 1sa1, 1z2b – rSTM + tubulin + GTP + GDP + anti-wart drug
    
  • 4eb6, 5j2u – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug
    
  • 3du7 – rSTM + tubulin + GTP + GDP + phomopsine + anti-gout drug
    
  • 3e22 – rSTM + tubulin + GTP + GDP + soblidotine + anti-gout drug
    
  • 5lp6, 5kx5 – rSTM + tubulin + GTP + GDP + drug
    
  • 3ut5 – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + anti-gout drug + Vinca tetrapeptide
    

• Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase

• • 4iij – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP
    
  • 4ihj – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP
    
  • 5jqg, 6i5c, 4i55, 5xp3, 6jcj, [[6gze] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative
    
  • 5yl2, 5ylj, 5yls, 6br1, 6brf, 6bry, 6bs2, 6d88, 6fkj, 6fkl, 5o7a – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor
    
  • 5ov7 – rSTM + tubulin + protein + GTP + GDP + ACP + inhibitor
    
  • 5xkf – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor
    
  • 4o2a, 6k9vj, 6o5m, 6o5n, 6o61, 6qqn, 6agk, 5z4u, 5z4p, 5xi7, 5xi5, 5xhc, 5h7o, 6qtn – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor
    
  • 6hx8, 6eg5 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + quinoline derivative
    
  • 5lov, 5njh – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide
    
  • 5lxs, 5lxt – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide
    
  • 5lyj, 5mf4 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + natural product
    

• Stathmin SLD domain complex with tubulin, tubulin tyrosine ligase and drug

• • 5xiw – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + anti-gout drug
    
  • 5xke – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug
    
  • 4o2b – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug
    
  • 5xkh, 5h74, 5gon, 5ezy – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug
    
  • 4o4l, 5j2t, 5bmv, 5la6, 5jh7, 5jvd, 5fnv, 5c8y, 5ca0, 5ca1, 5cb4, 4yj2, 4yj3, 4x1i, 4x1k, 4x1y, 4x20, 4tuy, 4zol, 4tv8, 4tv9, 4o4j, 4o4l, 5i50, 4i4t, 4o4i, 4o2l, 5iyz, 5la6, 5m7e, 5m7g, 5m8d, 5m8g, 5xlt, 5yl4, 5xkg, 5xlt, 6fii, 6fjf, 6fjm, 5xlz, 4i50, 6knzj, 6n47, 6nng, 6gj4, 6gf3, 6f7c, 5zxh, 5yz3, 5xag, 5xaf, 5osk, 5ng1, 5nfz, 5jcb – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs
    

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References

1. ↑ Curmi PA, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Struct Funct. 1999 Oct;24(5):345-57. PMID:15216892
2. ↑ Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;(61):281-8. PMID:11771751