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Stathmin

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== Disease ==
== Disease ==
Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>.
Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>.
 +
 +
== 3D Structures of stathmin-4 ==
 +
[[Stathmin-4 3D structures]]
</StructureSection>
</StructureSection>
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**[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br />
**[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br />
**[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br />
**[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br />
 +
**[[6h9b]] – rSTM + tubulin + GTP + GDP + quinoline derivative <br />
*Stathmin SLD domain complex with tubulin and drugs
*Stathmin SLD domain complex with tubulin and drugs
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**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br />
**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br />
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br />
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br />
-
**[[5jqg]], [[6i5c]], [[4i55]], [[5xp3]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br />
+
**[[5jqg]], [[6i5c]], [[4i55]], [[5xp3]], [[6jcj]], [[6gze] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br />
**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]], [[5o7a]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br />
**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]], [[5o7a]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br />
 +
**[[5ov7]] – rSTM + tubulin + protein + GTP + GDP + ACP + inhibitor<br />
**[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br />
**[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br />
-
**[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br />
+
**[[4o2a]], [[6k9vj]], [[6o5m]], [[6o5n]], [[6o61]], [[6qqn]], [[6agk]], [[5z4u]], [[5z4p]], [[5xi7]], [[5xi5]], [[5xhc]], [[5h7o]], [[6qtn]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br />
 +
**[[6hx8]], [[6eg5]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + quinoline derivative<br />
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br />
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br />
**[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br />
**[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br />
Line 49: Line 55:
**[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug<br />
**[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug<br />
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br />
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br />
-
**[[5xkh]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br />
+
**[[5xkh]], [[5h74]], [[5gon]], [[5ezy]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br />
-
**[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]], [[4i50]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br />
+
**[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]], [[4i50]], [[6knzj]], [[6n47]], [[6nng]], [[6gj4]], [[6gf3]], [[6f7c]], [[5zxh]], [[5yz3]], [[5xag]], [[5xaf]], [[5osk]], [[5ng1]], [[5nfz]], [[5jcb]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:12, 10 February 2020

Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf)

Drag the structure with the mouse to rotate

3D Structures of stathmin-4

Updated on 10-February-2020 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Stathmin SLD domain complex with tubulin
    • 3ryf – rSTM + tubulin + GTP - rat
    • 3hkb, 3ryc, 3ryi – rSTM + tubulin + GTP + GDP
    • 3ryh – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate
    • 3hkc, 3n2g, 3n2k – rSTM + tubulin + GTP + GDP + pyridine derivative
    • 3hkd – rSTM + tubulin + GTP + GDP + pyrrolidine derivative
    • 3hke – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative
    • 6h9b – rSTM + tubulin + GTP + GDP + quinoline derivative
  • Stathmin SLD domain complex with tubulin and drugs
    • 1sa0 – rSTM + tubulin + GTP + GDP + anti-gout drug
    • 1sa1, 1z2b – rSTM + tubulin + GTP + GDP + anti-wart drug
    • 4eb6, 5j2u – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug
    • 3du7 – rSTM + tubulin + GTP + GDP + phomopsine + anti-gout drug
    • 3e22 – rSTM + tubulin + GTP + GDP + soblidotine + anti-gout drug
    • 5lp6, 5kx5 – rSTM + tubulin + GTP + GDP + drug
    • 3ut5 – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + anti-gout drug + Vinca tetrapeptide
  • Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase
    • 4iij – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP
    • 4ihj – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP
    • 5jqg, 6i5c, 4i55, 5xp3, 6jcj, [[6gze] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative
    • 5yl2, 5ylj, 5yls, 6br1, 6brf, 6bry, 6bs2, 6d88, 6fkj, 6fkl, 5o7a – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor
    • 5ov7 – rSTM + tubulin + protein + GTP + GDP + ACP + inhibitor
    • 5xkf – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor
    • 4o2a, 6k9vj, 6o5m, 6o5n, 6o61, 6qqn, 6agk, 5z4u, 5z4p, 5xi7, 5xi5, 5xhc, 5h7o, 6qtn – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor
    • 6hx8, 6eg5 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + quinoline derivative
    • 5lov, 5njh – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide
    • 5lxs, 5lxt – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide
    • 5lyj, 5mf4 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + natural product
  • Stathmin SLD domain complex with tubulin, tubulin tyrosine ligase and drug

}}

References

  1. ↑ Curmi PA, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Struct Funct. 1999 Oct;24(5):345-57. PMID:15216892
  2. ↑ Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;(61):281-8. PMID:11771751

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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