Tubulin tyrosine ligase

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== Structural highlights ==
== Structural highlights ==
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<scene name='70/707399/Cv/2'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/3'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/4'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>.
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<scene name='70/707399/Cv/5'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/6'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/7'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>.
</StructureSection>
</StructureSection>

Revision as of 13:14, 6 October 2019

Tubulin tyrosine ligase (cyan) complex with α-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code 4iij)

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3D Structures of tubulin tyrosine ligase

Updated on 06-October-2019

References

  1. ↑ Idriss HT. Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of alpha-tubulin tyrosination. Cell Motil Cytoskeleton. 2000 May;46(1):1-5. PMID:10842328 doi:<1::AID-CM1>3.0.CO;2-6 http://dx.doi.org/10.1002/(SICI)1097-0169(200005)46:1<1::AID-CM1>3.0.CO;2-6
  2. ↑ Szyk A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro. J Mol Biol. 2013 Jul 24;425(14):2412-4. doi: 10.1016/j.jmb.2013.04.017. Epub 2013, Apr 25. PMID:23624152 doi:http://dx.doi.org/10.1016/j.jmb.2013.04.017
  3. ↑ Lafanechere L, Courtay-Cahen C, Kawakami T, Jacrot M, Rudiger M, Wehland J, Job D, Margolis RL. Suppression of tubulin tyrosine ligase during tumor growth. J Cell Sci. 1998 Jan;111 ( Pt 2):171-81. PMID:9405300
  4. ↑ Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan , 28. PMID:23358242 doi:http://dx.doi.org/10.1083/jcb.201211017

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