6j2s
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of HitA bound to gallium from Pseudomonas aeruginosa== | |
| + | <StructureSection load='6j2s' size='340' side='right'caption='[[6j2s]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6j2s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J2S FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j2s OCA], [http://pdbe.org/6j2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j2s RCSB], [http://www.ebi.ac.uk/pdbsum/6j2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j2s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development. | ||
| - | + | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514<ref>PMID:31475514</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6j2s" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Guo, Y]] | [[Category: Guo, Y]] | ||
| - | [[Category: Li, H | + | [[Category: Li, H Y]] |
| - | [[Category: Sun, H | + | [[Category: Sun, H Z]] |
[[Category: Xia, W]] | [[Category: Xia, W]] | ||
| + | [[Category: Ferric iron binding protein]] | ||
| + | [[Category: Gallium]] | ||
| + | [[Category: Hita]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Metal-drug]] | ||
| + | [[Category: Transporter]] | ||
Revision as of 08:17, 1 January 2020
Structure of HitA bound to gallium from Pseudomonas aeruginosa
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