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6qa2

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Current revision (11:56, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6qa2' size='340' side='right'caption='[[6qa2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6qa2' size='340' side='right'caption='[[6qa2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6qa2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QA2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6qa2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QA2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ndk, MRA_2471 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qa2 OCA], [https://pdbe.org/6qa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qa2 RCSB], [https://www.ebi.ac.uk/pdbsum/6qa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qa2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qa2 OCA], [http://pdbe.org/6qa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qa2 RCSB], [http://www.ebi.ac.uk/pdbsum/6qa2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qa2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NDK_MYCTA NDK_MYCTA]] Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
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[https://www.uniprot.org/uniprot/NDK_MYCTU NDK_MYCTU] Major role in the synthesis of nucleoside triphosphates other than ATP.[HAMAP-Rule:MF_00451]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6qa2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6qa2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mycta]]
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[[Category: Mycobacterium tuberculosis H37Ra]]
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[[Category: Nucleoside-diphosphate kinase]]
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[[Category: Dautant A]]
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[[Category: Dautant, A]]
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[[Category: Engen JR]]
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[[Category: Engen, J R]]
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[[Category: Georgescauld F]]
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[[Category: Georgescauld, F]]
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[[Category: Henri J]]
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[[Category: Henri, J]]
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[[Category: Meyer P]]
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[[Category: Meyer, P]]
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[[Category: Wales TE]]
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[[Category: Wales, T E]]
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[[Category: Open and closed binding site]]
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[[Category: Remodeling]]
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[[Category: Transferase]]
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Current revision

R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS

PDB ID 6qa2

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