4c9y

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Revision as of 17:33, 7 September 2022

Structural Basis for the microtubule binding of the human kinetochore Ska complex

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 <StructureSection load='4c9y' size='340' side='right'caption='[[4c9y]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4c9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4c9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C9Y FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ca0|4ca0]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9y OCA], [https://pdbe.org/4c9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c9y RCSB], [https://www.ebi.ac.uk/pdbsum/4c9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9y ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9y OCA], [http://pdbe.org/4c9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c9y RCSB], [http://www.ebi.ac.uk/pdbsum/4c9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9y ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref>
+[[https://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The ability of kinetochores (KTs) to maintain stable attachments to dynamic microtubule structures ('straight' during microtubule polymerization and 'curved' during microtubule depolymerization) is an essential requirement for accurate chromosome segregation. Here we show that the kinetochore-associated Ska complex interacts with tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural basis for the ability to bind both straight and curved microtubule structures. This contrasts with the Ndc80 complex, which binds straight microtubules by recognizing the dimeric interface of tubulin. The Ska1 microtubule-binding domain interacts with tubulins using multiple contact sites that allow the Ska complex to bind microtubules in multiple modes. Disrupting either the flexibility or the tubulin contact sites of the Ska1 microtubule-binding domain perturbs normal mitotic progression, explaining the critical role of the Ska complex in maintaining a firm grip on dynamic microtubules.
-Structural basis for microtubule recognition by the human kinetochore Ska complex.,Abad MA, Medina B, Santamaria A, Zou J, Plasberg-Hill C, Madhumalar A, Jayachandran U, Redli PM, Rappsilber J, Nigg EA, Jeyaprakash AA Nat Commun. 2014 Jan 13;5:2964. doi: 10.1038/ncomms3964. PMID:24413531<ref>PMID:24413531</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4c9y" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Abad, M]]
+[[Category: Abad M]]
-[[Category: Jayachandran, U]]
+[[Category: Jayachandran U]]
-[[Category: Jeyaprakash, A A]]
+[[Category: Jeyaprakash AA]]
-[[Category: Madhumalar, A]]
+[[Category: Madhumalar A]]
-[[Category: Medina, B]]
+[[Category: Medina B]]
-[[Category: Nigg, E A]]
+[[Category: Nigg EA]]
-[[Category: Plasberg-Hill, C]]
+[[Category: Plasberg-Hill C]]
-[[Category: Rappsilber, J]]
+[[Category: Rappsilber J]]
-[[Category: Redli, P M]]
+[[Category: Redli PM]]
-[[Category: Santamaria, A]]
+[[Category: Santamaria A]]
-[[Category: Zou, J]]
+[[Category: Zou J]]
-[[Category: Cell cycle]]
-[[Category: Cell divison]]
-[[Category: Kinetochore-microtubule attachment]]
-[[Category: Winged-helix domain]]

4c9y

From Proteopedia

Revision as of 17:33, 7 September 2022

Structural Basis for the microtubule binding of the human kinetochore Ska complex

Structural highlights

Function

References

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