This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4cb9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4cb9' size='340' side='right'caption='[[4cb9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4cb9' size='340' side='right'caption='[[4cb9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4cb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB9 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4cb9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB9 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cb8|4cb8]], [[4cba|4cba]]</td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb9 OCA], [https://pdbe.org/4cb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb9 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb9 OCA], [http://pdbe.org/4cb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb9 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
+
[[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-alphas. CTNNBL1 comprises a HEAT-like domain (including a nuclear export signal), a central armadillo domain, and a coiled-coil C-terminal domain. Structure-guided mutations of the region homologous to the karyopherin-alpha NLS-binding site fail to disrupt CTNNBL1-NLS interactions. Our results identify CTNNBL1 as a unique selective NLS-binding protein with striking differences from karyopherin-alphas.
+
-
 
+
-
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha,Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C FEBS Lett. 2013 Nov 20. pii: S0014-5793(13)00847-8. doi:, 10.1016/j.febslet.2013.11.013. PMID:24269683<ref>PMID:24269683</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4cb9" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ganesh, K]]
+
[[Category: Ganesh K]]
-
[[Category: Johnson, C M]]
+
[[Category: Johnson CM]]
-
[[Category: Neuberger, M S]]
+
[[Category: Neuberger MS]]
-
[[Category: Rada, C]]
+
[[Category: Rada C]]
-
[[Category: Simpson, P]]
+
[[Category: Simpson P]]
-
[[Category: Telerman, S B]]
+
[[Category: Telerman SB]]
-
[[Category: Williams, R L]]
+
[[Category: Williams RL]]
-
[[Category: VanMaldegem, F]]
+
[[Category: VanMaldegem F]]
-
[[Category: Aid]]
+
-
[[Category: Apoptosis]]
+
-
[[Category: Deaminase]]
+
-
[[Category: Import]]
+

Revision as of 17:36, 7 September 2022

Structure of full-length CTNNBL1 in P43212 space group

PDB ID 4cb9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cb9"
Personal tools