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4c5r
From Proteopedia
(Difference between revisions)
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<StructureSection load='4c5r' size='340' side='right'caption='[[4c5r]], [[Resolution|resolution]] 2.14Å' scene=''> | <StructureSection load='4c5r' size='340' side='right'caption='[[4c5r]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4c5r]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4c5r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C5R FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQ7:(3S)-3-AMINO-2,2-DIFLUORO-3-PHENYLPROPANOIC+ACID'>BQ7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BQ7:(3S)-3-AMINO-2,2-DIFLUORO-3-PHENYLPROPANOIC+ACID'>BQ7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5r OCA], [https://pdbe.org/4c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c5r RCSB], [https://www.ebi.ac.uk/pdbsum/4c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c5r ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | + | == Function == | |
| - | = | + | [[https://www.uniprot.org/uniprot/PAM_TAXWC PAM_TAXWC]] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first commited step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref> |
| - | Phenylalanine | + | |
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| - | </ | + | |
| - | < | + | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chinese yew]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Taxus chinensis]] |
| - | [[Category: Dijkstra | + | [[Category: Dijkstra BW]] |
| - | [[Category: Feringa | + | [[Category: Feringa BL]] |
| - | [[Category: Janssen | + | [[Category: Janssen DB]] |
| - | [[Category: Szymanski | + | [[Category: Szymanski W]] |
| - | [[Category: Wu | + | [[Category: Wu B]] |
| - | [[Category: Wybenga | + | [[Category: Wybenga GG]] |
| - | + | ||
Revision as of 17:28, 7 September 2022
Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus chinensis
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