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Asparaginase
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of asparaginase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *ASP I | ||
| - | |||
| - | **[[1hfj]], [[1hfk]], [[1o7j]] - ErcASP – ''Erwinia chrysanthemi''<br /> | ||
| - | **[[1wnf]], [[1wls]] - ASP – ''Pyrococcus horikoshii''<br /> | ||
| - | **[[1zcf]] - PaASP – ''Pectobacterium atrosepticum''<br /> | ||
| - | **[[2gez]] - ASP – yellow lupine<br /> | ||
| - | **[[2ocd]] - ASP – ''Vibrio cholera''<br /> | ||
| - | **[[2p2d]] - EcASP – ''Eschericia coli''<br /> | ||
| - | **[[3ntx]] - ASP – ''Yersinia pestis''<br /> | ||
| - | **[[3nxk]] - ASP – ''Campylobacter jejuni''<br /> | ||
| - | **[[4pvq]], [[4et0]] - hASP – human<br /> | ||
| - | **[[3tkj]] - hASP (mutant) <br /> | ||
| - | **[[4pu6]], [[4pv2]], [[4pv3]] – ASP – bean<br /> | ||
| - | **[[4q0m]], [[4ra6]], [[4ra9]], [[5cbp]] – PfASP – ''Pyrococcus furiosus''<br /> | ||
| - | **[[5ot0]] - ASP – ''Thermococcus kodakarensis'' <br /> | ||
| - | |||
| - | *ASP I complex | ||
| - | |||
| - | **[[1hfw]], [[5hw0]] - ErcASP + glutamate<br /> | ||
| - | **[[2hln]] - PaASP + glutamate<br /> | ||
| - | **[[1hg0]] - ErcASP + succinate<br /> | ||
| - | **[[1hg1]] - ErcASP + D-AA<BR /> | ||
| - | **[[5f52]] - ErcASP + L-AA<br /> | ||
| - | **[[5ilz]], [[5i48]], [[5i4b]] - ErcASP (mutant) + L-AA<br /> | ||
| - | **[[2gvn]] - PaSP + AA<BR /> | ||
| - | **[[2jk0]] - ASP + AA – ''Pectobacterium carotovorum''<br /> | ||
| - | **[[2wlt]], [[2wt4]] - ASP + AA – ''Helicobacter pylori''<br /> | ||
| - | **[[2him]], [[2zal]] - EcASP + AA<BR /> | ||
| - | **[[2p2n]] - EcASP + asparagine + AA<BR /> | ||
| - | **[[1jsl]], [[1jsr]] - ErcASP + norleucine<br /> | ||
| - | **[[4pvp]] - hASP + malonate<br /> | ||
| - | **[[4pvp]] - hASP + sulfate<br /> | ||
| - | **[[4pvr]], [[4pvs]] - hASP + AA<BR /> | ||
| - | **[[4nje]] – ASP + Asp – ''Pyrococcus horikoshii''<br /> | ||
| - | **[[5b5u]], [[5b74]] - PfLASP + peptide<br /> | ||
| - | **[[5i3z]] - ASP (mutant) + Asp – ''Dickeya chrysanthemi'' <br /> | ||
| - | **[[5k4g]] - WsASP + L-Asp - ''Wolinella succinogenes'' <br /> | ||
| - | **[[5k3o]] - WsASP (mutant) + L-Asp <br /> | ||
| - | **[[5k4h]] - WsASP + L-Glu <br /> | ||
| - | **[[5k45]] - WsASP (mutant) + L-Glu <br /> | ||
| - | **[[5dne]], [[5dnd]], [[5dnc]] – ASP (mutant) + asparagine – guinea pig<br /> | ||
| - | |||
| - | *ASP II | ||
| - | |||
| - | **[[1wsa]] – WsASP precursor <br /> | ||
| - | **[[6eok]] - EcASP (mutant)<br /> | ||
| - | **[[1ihd]], [[1jaz]], [[1jja]], [[5mq5]] - EcASP (mutant) | ||
| - | |||
| - | *ASP II complex | ||
| - | |||
| - | **[[3eca]], [[4eca]], [[1nns]] – EcASP + AA<BR /> | ||
| - | **[[1ho3]] - EcASP (mutant) + AA<BR /> | ||
| - | |||
| - | *Isoaspartyl peptidase/L-asparaginase | ||
| - | |||
| - | **[[4o0c]], [[4zm9]] - hIPA <br /> | ||
| - | **[[4o0d]], [[4o0e]], [[4o0f]], [[4o0g]] - hIPA (mutant)<br /> | ||
| - | **[[4o0h]] - hIPA + L-Asp<br /> | ||
| - | **[[4osx]], [[4osy]] - hIPA + Gly<br /> | ||
| - | |||
| - | *Glycosylasparaginase or N(4)-(b-N-acetylglucosaminyl)-L-asparaginase | ||
| - | |||
| - | **[[9gaa]] - EmGASP – Elizabethkingia meningoseptica<br /> | ||
| - | **[[9gac]], [[9gaf]], [[5v2i]], [[3ljq]] - EmGASP (mutant) <br /> | ||
| - | **[[2gl9]], [[4r4y]] - EmGASP (mutant) + Asn<br /> | ||
| - | |||
| - | *Glutaminase-asparaginase see [[Glutaminase]] | ||
| - | |||
| - | **[[2zak]], [[3c17]] - EcASP precursor (mutant) | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:16, 20 March 2019
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References
- ↑ Prahl A, Pazgier M, Hejazi M, Lockau W, Lubkowski J. Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1173-6. Epub 2004, May 21. PMID:15159592 doi:10.1107/S0907444904003403
- ↑ Wang Y, Guo HC. Crystallographic snapshot of a productive glycosylasparaginase-substrate complex. J Mol Biol. 2007 Feb 9;366(1):82-92. Epub 2006 Sep 26. PMID:17157318 doi:10.1016/j.jmb.2006.09.051
- ↑ Xu F, Oruna-Concha MJ, Elmore JS. The use of asparaginase to reduce acrylamide levels in cooked food. Food Chem. 2016 Nov 1;210:163-71. doi: 10.1016/j.foodchem.2016.04.105. Epub 2016 , Apr 22. PMID:27211635 doi:http://dx.doi.org/10.1016/j.foodchem.2016.04.105
- ↑ Kwok CS, Kham SK, Ariffin H, Lin HP, Quah TC, Yeoh AE. Escherichia coli-asparaginase (Elspar) is superior to Erwinia-asparaginase (Erwinase) in childhood acute lymphoblastic leukaemia (ALL) induction--an early response study using minimal residual disease (MRD) markers. Ann Acad Med Singapore. 2004 Sep;33(5 Suppl):S45-6. PMID:15651203
- ↑ Aronson NN Jr. Aspartylglycosaminuria: biochemistry and molecular biology. Biochim Biophys Acta. 1999 Oct 8;1455(2-3):139-54. PMID:10571008
- ↑ Yun MK, Nourse A, White SW, Rock CO, Heath RJ. Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I. J Mol Biol. 2007 Jun 8;369(3):794-811. Epub 2007 Mar 30. PMID:17451745 doi:http://dx.doi.org/10.1016/j.jmb.2007.03.061
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