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4c47

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<StructureSection load='4c47' size='340' side='right'caption='[[4c47]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='4c47' size='340' side='right'caption='[[4c47]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c47]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C47 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c47]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C47 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c46|4c46]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c47 OCA], [https://pdbe.org/4c47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c47 RCSB], [https://www.ebi.ac.uk/pdbsum/4c47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c47 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c47 OCA], [http://pdbe.org/4c47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c47 RCSB], [http://www.ebi.ac.uk/pdbsum/4c47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c47 ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/SADB_SALTY SADB_SALTY]] Required for proper surface expression of the autotransporter adhesin SadA. Could be directly involved in the biogenesis of functionally active SadA.<ref>PMID:24369174</ref>
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Trimeric Autotransporter Adhesins (TAAs) are important virulence factors of many gram-negative bacterial pathogens. TAAs form fibrous, adhesive structures on the bacterial cell surface. Their N-terminal, extracellular domains are exported through a C-terminal membrane pore; the insertion of the pore domain into the bacterial outer membrane follows the rules of beta-barrel transmembrane protein biogenesis and is dependent on the essential Bam complex. We have recently described the full fiber structure of SadA, a TAA of unknown function in Salmonella and other enterobacteria. In this work, we describe the structure and function of SadB, a small inner membrane lipoprotein. The sadB gene is located in an operon with sadA; orthologous operons are only found in enterobacteria, while other TAAs are not typically associated with lipoproteins. Strikingly, SadB is also a trimer, and its co-expression with SadA has a direct influence on SadA structural integrity. This is the first report of a specific export factor of a TAA, suggesting that at least in some cases, TAA autotransport is assisted by additional periplasmic proteins.
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A Trimeric Lipoprotein assists in Trimeric Autotransporter Biogenesis in Enterobacteria.,Grin I, Hartmann MD, Sauer G, Hernandez Alvarez B, Schutz M, Madlung J, Macek B, Felipe-Lopez A, Hensel M, Lupas A, Linke D J Biol Chem. 2013 Dec 25. PMID:24369174<ref>PMID:24369174</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4c47" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Salty]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Grin, I]]
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[[Category: Grin I]]
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[[Category: Hartmann, M D]]
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[[Category: Hartmann MD]]
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[[Category: Linke, D]]
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[[Category: Linke D]]
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[[Category: Autotransport]]
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[[Category: Bacterial adhesion]]
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[[Category: Cell adhesion]]
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[[Category: Membrane insertion]]
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[[Category: Membrane trafficking]]
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[[Category: Polar core residue]]
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Revision as of 17:25, 7 September 2022

Salmonella enterica trimeric lipoprotein SadB

PDB ID 4c47

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