4cqw

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<StructureSection load='4cqw' size='340' side='right'caption='[[4cqw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4cqw' size='340' side='right'caption='[[4cqw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cqw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/turkey/1/2005(h5n1)) Influenza a virus (a/turkey/turkey/1/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cqw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/turkey/Turkey/1/2005(H5N1)) Influenza A virus (A/turkey/Turkey/1/2005(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqx|4cqx]], [[4cqy|4cqy]], [[4cqz|4cqz]], [[4cr0|4cr0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqw OCA], [https://pdbe.org/4cqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqw RCSB], [https://www.ebi.ac.uk/pdbsum/4cqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqw OCA], [http://pdbe.org/4cqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cqw RCSB], [http://www.ebi.ac.uk/pdbsum/4cqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q207Z6_9INFA Q207Z6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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[[https://www.uniprot.org/uniprot/Q207Z6_9INFA Q207Z6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Collins, P J]]
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[[Category: Collins PJ]]
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[[Category: Coombs, P J]]
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[[Category: Coombs PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Gamblin SJ]]
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[[Category: Lin, Y P]]
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[[Category: Lin YP]]
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[[Category: Liu, J]]
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[[Category: Liu J]]
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[[Category: Martin, S R]]
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[[Category: Martin SR]]
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[[Category: McCauley, J W]]
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[[Category: McCauley JW]]
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[[Category: Skehel, J J]]
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[[Category: Skehel JJ]]
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[[Category: Vachieri, S G]]
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[[Category: Vachieri SG]]
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[[Category: Walker, P A]]
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[[Category: Walker PA]]
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[[Category: Xiao, H]]
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[[Category: Xiao H]]
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[[Category: Xiong, X]]
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[[Category: Xiong X]]
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[[Category: 3'sln]]
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[[Category: 6'sln]]
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[[Category: Avian flu]]
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[[Category: Glycoprotein]]
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[[Category: Haemagglutinin]]
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[[Category: Lsta]]
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[[Category: Sialic acid]]
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[[Category: Sialyllactosamine]]
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[[Category: Viral protein]]
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[[Category: Virus receptor]]
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Revision as of 07:28, 14 September 2022

H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN

PDB ID 4cqw

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