4crt

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Current revision (07:29, 14 September 2022) (edit) (undo)
 
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<StructureSection load='4crt' size='340' side='right'caption='[[4crt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4crt' size='340' side='right'caption='[[4crt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4crt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crt OCA], [https://pdbe.org/4crt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4crt RCSB], [https://www.ebi.ac.uk/pdbsum/4crt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4crt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4crt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crt OCA], [http://pdbe.org/4crt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4crt RCSB], [http://www.ebi.ac.uk/pdbsum/4crt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4crt ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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[[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Monoamine oxidase]]
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[[Category: Allan J]]
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[[Category: Allan, J]]
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[[Category: Binda C]]
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[[Category: Binda, C]]
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[[Category: Esteban G]]
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[[Category: Esteban, G]]
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[[Category: Marco-Contelles J]]
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[[Category: Marco-Contelles, J]]
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[[Category: Mattevi A]]
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[[Category: Mattevi, A]]
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[[Category: Ramsay RR]]
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[[Category: Ramsay, R R]]
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[[Category: Samadi A]]
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[[Category: Samadi, A]]
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[[Category: Unzeta M]]
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[[Category: Unzeta, M]]
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[[Category: Alzheimer's disease]]
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[[Category: Drug design]]
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[[Category: Enzyme]]
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[[Category: Flavin]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234

PDB ID 4crt

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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