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4cpb

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<StructureSection load='4cpb' size='340' side='right'caption='[[4cpb]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
<StructureSection load='4cpb' size='340' side='right'caption='[[4cpb]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cpb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cpb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CN8:(4S)-N-ETHYL-4-{[N-METHYL-3-(1-{2-[(4-SULFANYLBENZOYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)-L-ALANYL]AMINO}-L-PROLINAMIDE'>CN8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CN8:(4S)-N-ETHYL-4-{[N-METHYL-3-(1-{2-[(4-SULFANYLBENZOYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)-L-ALANYL]AMINO}-L-PROLINAMIDE'>CN8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRO:2-HYDROXY-TRYPTOPHAN'>TRO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=TRO:2-HYDROXY-TRYPTOPHAN'>TRO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpb OCA], [https://pdbe.org/4cpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpb RCSB], [https://www.ebi.ac.uk/pdbsum/4cpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpb ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cp9|4cp9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpb OCA], [http://pdbe.org/4cpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cpb RCSB], [http://www.ebi.ac.uk/pdbsum/4cpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
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[[https://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseae]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Imberty, A]]
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[[Category: Imberty A]]
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[[Category: Topin, J]]
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[[Category: Topin J]]
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[[Category: Varrot, A]]
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[[Category: Varrot A]]
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[[Category: Wissinger, N]]
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[[Category: Wissinger N]]
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[[Category: Galactose binding]]
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[[Category: Sugar based inhibitor]]
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[[Category: Sugar binding protein]]
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Revision as of 07:25, 14 September 2022

CRYSTAL STRUCTURE OF LECA IN COMPLEX WITH A DIVALENT GALACTOSIDE AT 1. 57 ANGSTROM IN MAGNESIUM

PDB ID 4cpb

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