Acetylcholinesterase 3D structures

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*Acetylcholinesterase - AChE native
*Acetylcholinesterase - AChE native
 +
**[[6o69]] – hAChE (mutant) - human <br />
**[[3lii]], [[4ey4]], [[4pqe]], [[5hq3]] – hAChE - recombinant human <br />
**[[3lii]], [[4ey4]], [[4pqe]], [[5hq3]] – hAChE - recombinant human <br />
**[[1ea5]], [[2ace]], [[2j3d]], [[1w75]], [[2vt6]], [[2vt7]] – ''Tc''AChE – ''Torpedo californica'' <br />
**[[1ea5]], [[2ace]], [[2j3d]], [[1w75]], [[2vt6]], [[2vt7]] – ''Tc''AChE – ''Torpedo californica'' <br />
**[[1qid]] to [[1qim]] - ''Tc''AChE synchrotron radiation damage <br />
**[[1qid]] to [[1qim]] - ''Tc''AChE synchrotron radiation damage <br />
**[[1j06]], [[1maa]], [[5dti]] – mAChE - mouse <br />
**[[1j06]], [[1maa]], [[5dti]] – mAChE - mouse <br />
-
**[[1qo9]] – ''Dm''AChE - ''Drosophila melanogaster'' <br />
+
**[[1qo9]], [[6xys]] – ''Dm''AChE - ''Drosophila melanogaster'' <br />
**[[1eea]], [[1c2b]], [[1c2o]] – AChE – Electric eel <br />
**[[1eea]], [[1c2b]], [[1c2o]] – AChE – Electric eel <br />
**[[5x61]], [[5ydh]], [[5ydi]] – mmAChE – malaria mosquito<br />
**[[5x61]], [[5ydh]], [[5ydi]] – mmAChE – malaria mosquito<br />
**[[6arx]] – mmAChE (mutant) <br />
**[[6arx]] – mmAChE (mutant) <br />
 +
**[[6uqv]] – PaAChE – ''Pseudomonas aeruginosa'' <br />
 +
**[[6ur0]] – PaAChE (mutant) <br />
*AChE inhibitors (In Different Languages)
*AChE inhibitors (In Different Languages)
Line 67: Line 70:
**[[4ey5]] – hAChE + huperzine<br />
**[[4ey5]] – hAChE + huperzine<br />
**[[4m0e]], [[4m0f]] - hAChE + inhibitor<br />
**[[4m0e]], [[4m0f]] - hAChE + inhibitor<br />
 +
**[[6o5v]], [[6o5s]], [[5o5r]], [[6u3p]], [[6u34]], [[6u37]], [[6nea]] - hAChE + oxime reactivator<br />
 +
**[[6o4x]] - hAChE + acridine derivative<br />
*''Drosophila melanogaster'' AChE active site inhibitors conjugating at the bottom of the active site gorge
*''Drosophila melanogaster'' AChE active site inhibitors conjugating at the bottom of the active site gorge
-
**[[1dx4]], [[1qon]] – ''Dm''AChE + tacrine derivative <br />
+
**[[1dx4]], [[1qon]], [[6xyu]], [[6xyy]] – ''Dm''AChE + tacrine derivative <br />
*AChE peripheral site inhibitors conjugating at the surface of the protein
*AChE peripheral site inhibitors conjugating at the surface of the protein
 +
**[[1b41]], [[1f8u]], [[4ey8]] - hAChE + fasciculin 2 <br />
 +
**[[2x8b]] - hAChE + fasciculin 2 + tabun<br />
 +
**[[4bdt]] - hAChE + fasciculin 2 + huprine W<br />
**[[1ku6]], [[1mah]] - mAChE + fasciculin 2 <br />
**[[1ku6]], [[1mah]] - mAChE + fasciculin 2 <br />
**[[1j07]] - mAChE + decidium <br />
**[[1j07]] - mAChE + decidium <br />
**[[1n5m]] - mAChE + gallamine <br />
**[[1n5m]] - mAChE + gallamine <br />
-
**[[1n5r]] - mAChE + propidium <br />
+
**[[1n5r]] - mAChE + propidium <br />
-
**[[1b41]], [[1f8u]], [[4ey8]] - hAChE + fasciculin 2 <br />
+
**[[1fss]] - TcAChE + fasciculin 2 <br />
**[[1fss]] - TcAChE + fasciculin 2 <br />
-
**[[2x8b]] - hAChE + fasciculin 2 + tabun<br />
 
-
**[[4bdt]] - hAChE + fasciculin 2 + huprine W<br />
 
*AChE bis inhibitors spanning the active site gorge
*AChE bis inhibitors spanning the active site gorge
 +
**[[4ey6]] - hAChE + galanthamine<br />
 +
**[[4ey7]], [[5nau]], [[5nap]], [[6o4w]] - hAChE + donepezil derivative<br />
 +
**[[6o50]], [[6o52]] – hAChE + bw284c51 <br />
 +
**[[1q83]], [[1q84]], [[5eie]], [[5eih]] - mAChE + TZ2 derivative <br />
 +
**[[5fkj]] - mAChE + uracil derivative<br />
 +
**[[5foq]] - mAChE + ligand<br />
**[[3i6m]], [[3i6z]], [[1w4l]], [[1w6r]], [[1w76]], [[1dx6]], [[1qti]] – ''Tc''AChE + galanthamine derivative <br />
**[[3i6m]], [[3i6z]], [[1w4l]], [[1w6r]], [[1w76]], [[1dx6]], [[1qti]] – ''Tc''AChE + galanthamine derivative <br />
**[[1zgb]], [[1zgc]] – ''Tc''AChE + tacrine (10) hupyridone <br />
**[[1zgb]], [[1zgc]] – ''Tc''AChE + tacrine (10) hupyridone <br />
**[[2w6c]] – ''Tc''AChE + bis-(-)-nor-meptazinol <br />
**[[2w6c]] – ''Tc''AChE + bis-(-)-nor-meptazinol <br />
**[[2ckm]], [[2cmf]] – ''Tc''AChE + bis-tacrine <br />
**[[2ckm]], [[2cmf]] – ''Tc''AChE + bis-tacrine <br />
-
**[[2cek]] – ''Tc''AChE + N-[8-(1,2,3,4-tetrahydroacridin-9-ylthio)octyl]-1,2,3,4-tetrahydroacridin-9-amine <br />
+
**[[1odc]], [[2cek]], [[1ut6]], [[6h13]], [[6h12]], [[6h14]] - ''Tc''AChE + acridine derivative <br />
-
**[[1ut6]] - ''Tc''AChE + N-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane <br />
+
-
**[[1odc]] - ''Tc''AChE + N-4-quinolyl-N-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane <br />
+
**[[1h22]], [[1h23]] – ''Tc''AChE + bis-hupyridone <br />
**[[1h22]], [[1h23]] – ''Tc''AChE + bis-hupyridone <br />
**[[1hbj]] – ''Tc''AChE + quinoline derivativev <br />
**[[1hbj]] – ''Tc''AChE + quinoline derivativev <br />
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**[[2xud]] – ''Tc''AChE (mutant) + decamethonium<br />
**[[2xud]] – ''Tc''AChE (mutant) + decamethonium<br />
**[[3zv7]] - ''Tc''AChE + bisnorcymserine<br />
**[[3zv7]] - ''Tc''AChE + bisnorcymserine<br />
-
**[[4ey6]] - hAChE + galanthamine<br />
 
-
**[[4ey7]], [[5nau]], [[5nap]] - hAChE + donepezil derivative<br />
 
-
**[[1q83]], [[1q84]], [[5eie]], [[5eih]] - mAChE + TZ2 derivative <br />
 
-
**[[5fkj]] - mAChE + uracil derivative<br />
 
-
**[[5foq]] - mAChE + ligand<br />
 
*AChE organophosphate inhibitors causing irreversible inhibition
*AChE organophosphate inhibitors causing irreversible inhibition
Line 155: Line 159:
**[[2c5f]] – ''Tc''AChE + substrate analog<br />
**[[2c5f]] – ''Tc''AChE + substrate analog<br />
**[[2va9]] - ''Tc''AChE + ‘caged’ arsenocholine<br />
**[[2va9]] - ''Tc''AChE + ‘caged’ arsenocholine<br />
-
**[[4ey7]] – hAChE + donepezil<br />
+
**[[6ur1]], [[6uqz]], [[6uqw]], [[6uqy]], [[6uqx]] – PaAChE (mutant) + thiocholine derivative<br />
*Others...
*Others...

Revision as of 07:58, 27 May 2020

3D Structures of Acetylcholinesterase

Updated on 27-May-2020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

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