User:Jaime Prilusky/Test/5ire

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(New page: ==Your Heading Here (maybe something like 'Structure')== <SX load='5ire' viewer='molstar' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for ...)
Current revision (09:14, 23 June 2019) (edit) (undo)
 
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==Your Heading Here (maybe something like 'Structure')==
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==The cryo-EM structure of Zika Virus==
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<SX load='5ire' viewer='molstar' size='340' side='right' caption='Caption for this structure' scene=''>
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<SX viewer='molstar' load='5ire' size='340' side='right' caption='[[5ire]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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This is a default text for your page '''Jaime Prilusky/Test/5ire'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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== Structural highlights ==
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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<table><tr><td colspan='2'>[[5ire]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ire FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ire OCA], [http://pdbe.org/5ire PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ire RCSB], [http://www.ebi.ac.uk/pdbsum/5ire PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ire ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome have generated worldwide concern. Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses. We present the 3.8 angstrom resolution structure of mature Zika virus, determined by cryo-electron microscopy (cryo-EM). The structure of Zika virus is similar to other known flavivirus structures, except for the ~10 amino acids that surround the Asn(154) glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, which is recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses, which suggests that differences in this region may influence virus transmission and disease.
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== Function ==
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The 3.8 A resolution cryo-EM structure of Zika virus.,Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ Science. 2016 Apr 22;352(6284):467-70. doi: 10.1126/science.aaf5316. Epub 2016, Mar 31. PMID:27033547<ref>PMID:27033547</ref>
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ire" style="background-color:#fffaf0;"></div>
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</SX>
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==See Also==
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*[[Art:Zika virus|Art:Zika virus]]
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*[[Virus coat protein|Virus coat protein]]
== References ==
== References ==
<references/>
<references/>
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__TOC__
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</StructureSection>
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[[Category: Zika virus]]
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[[Category: Chen, Z]]
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[[Category: Klose, T]]
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[[Category: Kuhn, R]]
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[[Category: Pierson, T]]
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[[Category: Rossmann, M]]
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[[Category: Sirohi, D]]
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[[Category: Sun, L]]
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[[Category: Virus]]

Current revision

The cryo-EM structure of Zika Virus

5ire, resolution 3.80Å

Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky

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