|
|
| Line 3: |
Line 3: |
| | <StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution|resolution]] 1.80Å' scene=''> | | <StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution|resolution]] 1.80Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LOU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT22, PP11246 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [https://pdbe.org/5lou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [https://www.ebi.ac.uk/pdbsum/5lou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/NUD22_HUMAN NUD22_HUMAN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 21: |
Line 23: |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Carter, M]] | + | [[Category: Carter M]] |
| - | [[Category: Stenmark, P]] | + | [[Category: Stenmark P]] |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Nudix]]
| + | |
| Structural highlights
Function
NUD22_HUMAN
Publication Abstract from PubMed
Human NUDT22 belongs to the diverse NUDIX family of proteins, but has, until now, remained uncharacterized. Here we show that human NUDT22 is a Mg(2+)-dependent UDP-glucose and UDP-galactose hydrolase, producing UMP and glucose 1-phosphate or galactose 1-phosphate. We present the structure of human NUDT22 alone and in a complex with the substrate UDP-glucose. These structures reveal a partially conserved NUDIX fold domain preceded by a unique N-terminal domain responsible for UDP moiety binding and recognition. The NUDIX domain of NUDT22 contains a modified NUDIX box identified using structural analysis and confirmed through functional analysis of mutants. Human NUDT22's distinct structure and function as a UDP-carbohydrate hydrolase establish a unique NUDIX protein subfamily.
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.,Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martinez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004. PMID:29413322[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martinez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004. PMID:29413322 doi:http://dx.doi.org/10.1016/j.str.2018.01.004
|
