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| | <StructureSection load='4eq2' size='340' side='right'caption='[[4eq2]], [[Resolution|resolution]] 2.50Å' scene=''> | | <StructureSection load='4eq2' size='340' side='right'caption='[[4eq2]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4eq2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQ2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4eq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQ2 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fg9|1fg9]], [[3dlq|3dlq]], [[1j7v|1j7v]], [[4eq3|4eq3]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq2 OCA], [https://pdbe.org/4eq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eq2 RCSB], [https://www.ebi.ac.uk/pdbsum/4eq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq2 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq2 OCA], [http://pdbe.org/4eq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eq2 RCSB], [http://www.ebi.ac.uk/pdbsum/4eq2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq2 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [[https://www.uniprot.org/uniprot/B4XN22_CHICK B4XN22_CHICK]] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Interferon receptor|Interferon receptor]] | + | *[[Interferon receptor 3D structures|Interferon receptor 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Chick]] | + | [[Category: Gallus gallus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gao, G F]] | + | [[Category: Gao GF]] |
| - | [[Category: Lu, G]] | + | [[Category: Lu G]] |
| - | [[Category: Ping, Z]] | + | [[Category: Ping Z]] |
| - | [[Category: Qi, J]] | + | [[Category: Qi J]] |
| - | [[Category: Shi, Y]] | + | [[Category: Shi Y]] |
| - | [[Category: Wang, M]] | + | [[Category: Wang M]] |
| - | [[Category: Wang, X]] | + | [[Category: Wang X]] |
| - | [[Category: Beta chain]]
| + | |
| - | [[Category: Ig-like structure]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Interferon gamma]]
| + | |
| - | [[Category: Ligand-binding]]
| + | |
| Structural highlights
Function
[B4XN22_CHICK]
Publication Abstract from PubMed
Interferon gamma (IFN-gamma) is an important cytokine that induces antiviral, antiproliferative, and immunomodulatory effects on target cells, and is also crucial in the early defense against intracellular parasites, such as Listeria monocytogenes and Toxoplasma gondii. The biological activity of IFN-gamma relies upon the formation of a complex with its 2 receptors, the interferon gamma alpha chain (IFNGR1) and beta chain (IFNGR2), which are type II cytokine receptors. Structural models of ligand-receptor interaction and complex structure of chicken IFNs with their receptors have remained elusive. Here we report the first structure of Gallus gallus (chicken) IFNGR1 (chIFNGR1) at 2.0 A by molecule replacement according to the structure of selenomethionine substituted chIFNGR1. The structural comparison reveals its structural similarities with other class II cytokine receptors, despite divergent primary sequences. We further investigate the ligand-receptor interaction properties of chicken IFN-gamma (chIFN-gamma) and chIFNGR1 using size-exclusion chromatography and surface plasmon resonance techniques. These data aid in the understanding of the interaction of chicken (avian) IFN-gamma with its receptors and its signal transduction.
Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts.,Ping Z, Qi J, Sun Y, Lu G, Shi Y, Wang X, Gao GF, Wang M J Interferon Cytokine Res. 2013 Nov 27. PMID:24283193[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ping Z, Qi J, Sun Y, Lu G, Shi Y, Wang X, Gao GF, Wang M. Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts. J Interferon Cytokine Res. 2013 Nov 27. PMID:24283193 doi:http://dx.doi.org/10.1089/jir.2012.0160
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