4esx

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<StructureSection load='4esx' size='340' side='right'caption='[[4esx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4esx' size='340' side='right'caption='[[4esx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4esx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canaw Canaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4esx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESX FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4esw|4esw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esx OCA], [https://pdbe.org/4esx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esx RCSB], [https://www.ebi.ac.uk/pdbsum/4esx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esx ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAWG_02199 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294748 CANAW])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esx OCA], [http://pdbe.org/4esx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4esx RCSB], [http://www.ebi.ac.uk/pdbsum/4esx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4esx ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THI5_CANAW THI5_CANAW] Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.<ref>PMID:22568620</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canaw]]
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[[Category: Candida albicans WO-1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Begley, T P]]
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[[Category: Begley TP]]
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[[Category: Ealick, S E]]
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[[Category: Ealick SE]]
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[[Category: Fenwick, M K]]
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[[Category: Fenwick MK]]
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[[Category: Hazra, A]]
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[[Category: Hazra A]]
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[[Category: Huang, S]]
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[[Category: Huang S]]
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[[Category: Kinsland, C]]
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[[Category: Kinsland C]]
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[[Category: Lai, R]]
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[[Category: Lai R]]
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[[Category: Philmus, B]]
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[[Category: Philmus B]]
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[[Category: Rajashankar, K]]
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[[Category: Rajashankar K]]
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[[Category: Sanders, J]]
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[[Category: Sanders J]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Thiamin pyrimidine biosynthesis]]
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[[Category: Transferase]]
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Revision as of 04:13, 7 October 2022

Crystal structure of C. albicans Thi5 complexed with PLP

PDB ID 4esx

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