2vnu

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{{STRUCTURE_2vnu| PDB=2vnu | SCENE= }}
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'''CRYSTAL STRUCTURE OF SC RRP44'''
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===CRYSTAL STRUCTURE OF SC RRP44===
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==Overview==
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The eukaryotic exosome is a macromolecular complex essential for RNA processing and decay. It has recently been shown that the RNase activity of the yeast exosome core can be mapped to a single subunit, Rrp44, which processively degrades single-stranded RNAs as well as RNAs containing secondary structures. Here we present the 2.3 A resolution crystal structure of S. cerevisiae Rrp44 in complex with single-stranded RNA. Although Rrp44 has a linear domain organization similar to bacterial RNase II, in three dimensions the domains have a different arrangement. The three domains of the classical nucleic-acid-binding OB fold are positioned on the catalytic domain such that the RNA-binding path observed in RNase II is occluded. Instead, RNA is threaded to the catalytic site via an alternative route suggesting a mechanism for RNA-duplex unwinding. The structure provides a molecular rationale for the observed biochemical properties of the RNase R family of nucleases.
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==About this Structure==
==About this Structure==
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[[Category: Rrna processing]]
[[Category: Rrna processing]]
[[Category: Rrp44]]
[[Category: Rrp44]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:45:08 2008''

Revision as of 05:45, 28 July 2008

Image:2vnu.png

Template:STRUCTURE 2vnu

CRYSTAL STRUCTURE OF SC RRP44

Template:ABSTRACT PUBMED 18374646

About this Structure

2VNU is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family., Lorentzen E, Basquin J, Tomecki R, Dziembowski A, Conti E, Mol Cell. 2008 Mar 28;29(6):717-28. PMID:18374646

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