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User:Courtney Brown/Sandbox 1
From Proteopedia
(Difference between revisions)
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==Introduction== | ==Introduction== | ||
| + | [https://en.wikipedia.org/wiki/Epigenetics Epigenetics] | ||
===Histones=== | ===Histones=== | ||
| + | [https://en.wikipedia.org/wiki/Histone Histones] | ||
| + | [https://en.wikipedia.org/wiki/Histone_deacetylase Histone Deacetylase] | ||
| + | [https://en.wikipedia.org/wiki/Histone_acetyltransferase Histone Acetyltransferase] | ||
| + | [https://en.wikipedia.org/wiki/Histone_methylation Histone Methylation] | ||
| + | [https://en.wikipedia.org/wiki/Demethylase Demethylation] | ||
===HDAC8=== | ===HDAC8=== | ||
| + | [https://en.wikipedia.org/wiki/HDAC8 Histone Deacetylase 8] | ||
==Structure== | ==Structure== | ||
| Line 23: | Line 30: | ||
==Deacetylation== | ==Deacetylation== | ||
| - | ===2+ Metal Ion Mechanism=== | + | ===Zn<sup>2+</sup> Metal Ion Mechanism=== |
| + | [[Image:Hdac mech.PNG|400 px|right|thumb|Figure 1. Mechanism of HDAC8]] | ||
===Active Site=== | ===Active Site=== | ||
| Line 30: | Line 38: | ||
==Disease== | ==Disease== | ||
| + | [https://friedreichsataxianews.com/friedreichs-ataxia-experimental-treatments/histone-deacetylase-inhibitors/ HDACis] | ||
== References == | == References == | ||
Revision as of 00:37, 31 March 2019
The Human Histone H3/K9 Deacetylase, HDAC8
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