Geranylgeranyl transferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres.
The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres.
 +
 +
==3D structures of geranylgeranyl transferase==
 +
[[Geranylgeranyl transferase 3D structures]]
 +
</StructureSection>
</StructureSection>
-
==3D structures of eranylgeranyl transferase==
+
==3D structures of geranylgeranyl transferase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Line 34: Line 38:
*Geranylgeranyl transferase type 2 complex
*Geranylgeranyl transferase type 2 complex
 +
**[[6o60]] – GGT2 β subunit + FBXL2 + SKP1 - human <br />
**[[3c72]], [[3pz1]], [[3pz3]], [[4ehm]], [[4gts]], [[4gtt]], [[4gtv]] – rGGT2 α+β subunits + inhibitor<br />
**[[3c72]], [[3pz1]], [[3pz3]], [[4ehm]], [[4gts]], [[4gtt]], [[4gtv]] – rGGT2 α+β subunits + inhibitor<br />
**[[3hxb]], [[3hxc]], [[3hxd]], [[3hxe]], [[3hxf]] – rGGT2 α (mutant) +β subunits + inhibitor<br />
**[[3hxb]], [[3hxc]], [[3hxd]], [[3hxe]], [[3hxf]] – rGGT2 α (mutant) +β subunits + inhibitor<br />

Revision as of 09:57, 9 July 2019

Structure of rat geranylgeranyl transferase type 2 subunits α (magenta) and β (cyan) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 3dst).

Drag the structure with the mouse to rotate

3D structures of geranylgeranyl transferase

Updated on 09-July-2019

References

  1. ↑ Lane KT, Beese LS. Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res. 2006 Apr;47(4):681-99. Epub 2006 Feb 13. PMID:16477080 doi:http://dx.doi.org/10.1194/jlr.R600002-JLR200
  2. ↑ Lawson MA, Coulton L, Ebetino FH, Vanderkerken K, Croucher PI. Geranylgeranyl transferase type II inhibition prevents myeloma bone disease. Biochem Biophys Res Commun. 2008 Dec 12;377(2):453-7. doi:, 10.1016/j.bbrc.2008.09.157. Epub 2008 Oct 16. PMID:18929536 doi:http://dx.doi.org/10.1016/j.bbrc.2008.09.157
  3. ↑ Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J. 2008 Sep 17;27(18):2444-56. Epub 2008 Aug 28. PMID:18756270 doi:10.1038/emboj.2008.164

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Geranylgeranyl_transferase"
Personal tools