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B-cell lymphoma protein

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[[Image:signal transduction.jpg|left|500px]]
[[Image:signal transduction.jpg|left|500px]]
{{Clear}}
{{Clear}}
 +
 +
==3D structures of B-cell lymphoma proteins==
 +
[[B-cell lymphoma proteins 3D structures]]
 +
</StructureSection>
</StructureSection>
==3D structures of B-cell lymphoma proteins==
==3D structures of B-cell lymphoma proteins==
Line 51: Line 55:
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
-
**[[2pon]] - hBcl-xL + Beclin-1- NMR<br />
+
**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
-
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />
+
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
Line 69: Line 72:
**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
 +
**[[6dcn]] - hBcl-xL + Beclin-1 BH3 domain<br />
 +
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
Line 108: Line 113:
**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
-
**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]] – hBcl-6 BTB domain + inhibitor<br />
+
**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
 +
**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
-
**[[2lce]] – hBcl-6 zinc fingers 2-3 - NMR<br />
+
**[[2lce]] – hBcl-6 zinc fingers 2-3 residues 540-602 - NMR<br />
 +
**[[2yrm]], [[2eos]] – hBcl-6 zinc finger-C2H2 residues 515-544 - NMR<br />
 +
**[[2en2]] – hBcl-6 zinc finger-C2H2 residues 598-626 - NMR<br />
*Bcl-9
*Bcl-9
-
**[[3sl9]] – hBcl-9 residues 344-396 + catenin beta-1<br />
+
**[[3sl9]] – hBcl-9 residues 344-396 + catenin β-1<br />
 +
**[[2gl7]] – hBcl-9 residues 344-396 + catenin β-1 + transcription factor 7-like<br />
*Bcl-10
*Bcl-10
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**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
 +
**[[6gk2]] – hBcl-10 CARD domain + MALTI death domain – Cryo EM<br />
*Bcl-W (Bcl-2-like protein 2)
*Bcl-W (Bcl-2-like protein 2)
Line 134: Line 144:
**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
-
**[[4bd8]] – hBax (mutant) <br />
+
**[[4bd8]], [[5w60]], [[5w61]] – hBax (mutant) <br />
**[[2lr1]] - hBax + VMIA peptide<br />
**[[2lr1]] - hBax + VMIA peptide<br />
**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
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**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
 +
**[[5w5z]], [[5w5x]] – hBax (mutant) + antibody<br />
*Bcl-2-like protein 5
*Bcl-2-like protein 5
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**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
-
**[[3mk8]] - hMcl-1 fragment<br />
+
**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
-
**[[2mhs]] - hMcl-1 fragment (mutant)<br />
+
**[[3mk8]] - hMcl-1 residues 174-324<br />
 +
**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
**[[4wms]] - hMcl-1/MBP (mutant) <br />
**[[4wms]] - hMcl-1/MBP (mutant) <br />
**[[5lof]] - hMcl-1/MBP + inhibitor<br />
**[[5lof]] - hMcl-1/MBP + inhibitor<br />
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**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
-
**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]] - hMcl-1 fragment + inhibitor<br />
+
**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]] - hMcl-1 residues 174-324 + inhibitor<br />
-
**[[5uum]] - hMcl-1 fragment + FS2 peptide <br />
+
**[[5uum]] - hMcl-1 residues 174-324 + FS2 peptide <br />
-
**[[5c3f]] - hMcl-1 fragment + BIB MM <br />
+
**[[6mbd]] - hMcl-1 residues 174-324 + DM1 peptide <br />
-
**[[5mes]], [[5mev]] - hMcl-1 fragment + inhibitor + antibody<br />
+
**[[6mbe]] - hMcl-1 residues 174-324 + DM7 peptide <br />
 +
**[[5c3f]] - hMcl-1 residues 174-324 + BIB MM <br />
 +
**[[5mes]], [[5mev]], [[6fs0]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
 +
**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />
*Mcl-1 complex with BH3 domain peptide
*Mcl-1 complex with BH3 domain peptide

Revision as of 08:53, 2 April 2019

NMR structure of bcl-2 1g5m

Drag the structure with the mouse to rotate

3D structures of B-cell lymphoma proteins

Updated on 02-April-2019

References

1. Mee Young Hong; Chapkin, Robert S.; Davidson, Laurie A.; Turner, Nancy D.; Morris, Jeffrey S.; Carroll, Raymond J.; Lupton, Joanne R.. Nutrition & Cancer, 2003, Vol. 46 Issue 1, p44-44, 8p; DOI: NO_DOI; (AN 10719727)

2. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG, Advances In Experimental Medicine And Biology, ISSN: 0065-2598, 1996; Vol. 406, pp. 99-112; PMID: 8910675

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