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B-cell lymphoma protein

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</StructureSection>
</StructureSection>
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==3D structures of B-cell lymphoma proteins==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Bcl-xL (Bcl-2-like protein 1)
 
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**[[1maz]], [[1r2d]], [[2b48]], [[4ppi]] – hBcl-xL – human<br />
 
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**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
 
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**[[2lpc]], [[2m03]], [[2me8]], [[2me9]], [[1lxl]] - hBcl-xL – NMR<br />
 
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**[[6bf2]] - hBcl-xL (mutant) – NMR<br />
 
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**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
 
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**[[2mej]] - hBcl-xL + p53 - NMR<br />
 
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**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
 
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**[[1ysg]], [[3sp7]], [[3spf]], [[3wiz]], [[4tuh]], [[3zln]], [[3zk6]], [[3zlo]], [[3zlr]], [[4c52]], [[4c5d]], [[2yxj]], [[4qnq]], [[4qvx]] - hBcl-xL + inhibitor<br />
 
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**[[2w3l]] – hBcl-xL + quinoline derivative<br />
 
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**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
 
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**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
 
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**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
 
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**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
 
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**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
 
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**[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
 
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**[[1pq1]], [[5c3g]] - mBcl-xL residues 1-196 + BIM peptide<br />
 
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**[[1af3]] - rBcl-xL soluble domain<br />
 
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**[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
 
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**[[5twa]] - Bcl-xL + Bak peptide – sponge<br />
 
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*Bcl-xL complex with BH3 domain peptide
 
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**[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
 
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**[[5fmk]], [[5fmj]] - hBcl-xL + Bak BH3 domain<br />
 
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**[[4qve]] - hBcl-xL + BID BH3 domain<br />
 
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**[[1g5j]] - hBcl-xL + BAD BH3 peptide <br />
 
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**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
 
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**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
 
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**[[6dcn]] - hBcl-xL + Beclin-1 BH3 domain<br />
 
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**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
 
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**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
 
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**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
 
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**[[4a1u]], [[4a1w]] - hBcl-xL + α/β-foldamer BH3 domain<br />
 
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**[[3r85]] - hBcl-xL + heme-binding protein BH3 peptide<br />
 
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**[[2lp8]] – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide - NMR<br />
 
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**[[2m04]] – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR<br />
 
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**[[5wos]] - Bcl-xL + hBIM BH3 domain – canarypox virus<br />
 
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**[[5tzp]] - fpvBcl-xL + BIK BH3 domain – fowlpox virus<br />
 
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**[[5tzq]] - fpvBcl-xL + Bmf BH3 domain <br />
 
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*Bcl-2
 
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**[[1gjh]], [[1g5m]] – hBcl-2<br />
 
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**[[4aq3]], [[4man]], [[5jsn]], [[4ieh]] – hBcl-2 + inhibitor<br />
 
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**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
 
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**[[5fcg]] – hBcl-2 (mutant) + HBX BH3 domain<br />
 
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**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain<br />
 
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**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative – NMR
 
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*Bcl-2-related protein A1 (Bfl-1)
 
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**[[5whi]] - hBcl-2A1 (mutant) <br />
 
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**[[2vm6]] – hBcl-2A1 + hBIM BH3 peptide<br />
 
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**[[2vof]] - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide <br />
 
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**[[2vog]] - mBcl-2A1 + Bmf BH3 peptide <br />
 
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**[[2voh]] - mBcl-2A1 + Bak BH3 peptide <br />
 
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**[[2voi]] - mBcl-2A1 + BID BH3 peptide <br />
 
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**[[3mqp]] - hBcl-2A1 + Noxa BH3 peptide <br />
 
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**[[5uul]] - hBcl-2A1 + PUMA BH3 peptide <br />
 
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**[[5uuk]], [[5uup]] - hBcl-2A1 + Bfl-1 peptide <br />
 
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**[[4zeq]] - hBcl-2A1 + BID BH3 peptide <br />
 
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*Bcl-3
 
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**[[1k1a]], [[1k1b]] – hBcl-3 ankyrin repeat domain <br />
 
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*Bcl-6
 
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**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
 
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**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
 
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**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
 
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**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
 
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**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
 
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**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
 
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**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
 
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**[[2lce]] – hBcl-6 zinc fingers 2-3 residues 540-602 - NMR<br />
 
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**[[2yrm]], [[2eos]] – hBcl-6 zinc finger-C2H2 residues 515-544 - NMR<br />
 
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**[[2en2]] – hBcl-6 zinc finger-C2H2 residues 598-626 - NMR<br />
 
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*Bcl-9
 
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**[[3sl9]] – hBcl-9 residues 344-396 + catenin β-1<br />
 
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**[[2gl7]] – hBcl-9 residues 344-396 + catenin β-1 + transcription factor 7-like<br />
 
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*Bcl-10
 
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**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
 
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**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
 
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**[[6gk2]] – hBcl-10 CARD domain + MALTI death domain – Cryo EM<br />
 
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*Bcl-W (Bcl-2-like protein 2)
 
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**[[1o0l]], [[1mk3]], [[2y6w]] – hBcl-W (mutant) <br />
 
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**[[1zy3]], [[4cim]] - hBcl-W (mutant) + BID BH3 peptide<br />
 
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**[[4k5a]], [[4k5b]] - Bcl-W (mutant) + ankyrin repeat - bovine<br />
 
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**[[4cin]] - hBcl-W + BH3 peptide<br />
 
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*Bcl-2-like protein 4 (Bax)
 
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**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
 
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**[[4bd8]], [[5w60]], [[5w61]] – hBax (mutant) <br />
 
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**[[2lr1]] - hBax + VMIA peptide<br />
 
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**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
 
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**[[2k7w]] – hBax + BIM BH3 peptide - NMR<br />
 
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**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
 
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**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
 
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**[[5w5z]], [[5w5x]] – hBax (mutant) + antibody<br />
 
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*Bcl-2-like protein 5
 
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**[[3i1h]] - hBcl-2-L-5 + hBak<br />
 
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*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
 
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**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBak<br />
 
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**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
 
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**[[4u2v]] – hBak/GFP<br />
 
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**[[3qbr]] - hBak + sjA<br />
 
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**[[2xpx]] - hBak fragment + BHRF1<br />
 
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**[[5vwx]], [[5vwy]], [[5vwz]], [[5vx0]] - hBak + BIM BH3 domain<br />
 
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**[[5vwv]] - hBak (mutant)+ BIM BH3 domain<br />
 
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**[[2m5b]] - hBak + BID BH3 domain - NMR<br />
 
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*Bcl-2-like protein 10
 
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**[[2kua]] – mBcl-2-L-10<br />
 
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**[[4b4s]] - hBcl-2-L-10 + hBIM BH3 peptide<br />
 
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*Bcl-2-like protein 11 (BIM)
 
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**[[2nl9]] – hBIM + Mcl-1<br />
 
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*Mcl-1 (Bcl-2-like protein 3)
 
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**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
 
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**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
 
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**[[3mk8]] - hMcl-1 residues 174-324<br />
 
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**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
 
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**[[4wms]] - hMcl-1/MBP (mutant) <br />
 
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**[[5lof]] - hMcl-1/MBP + inhibitor<br />
 
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**[[4wmx]], [[4wmw]], [[4wmv]] - hMcl-1/MBP + ligand<br />
 
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**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
 
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**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
 
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**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]] - hMcl-1 residues 174-324 + inhibitor<br />
 
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**[[5uum]] - hMcl-1 residues 174-324 + FS2 peptide <br />
 
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**[[6mbd]] - hMcl-1 residues 174-324 + DM1 peptide <br />
 
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**[[6mbe]] - hMcl-1 residues 174-324 + DM7 peptide <br />
 
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**[[5c3f]] - hMcl-1 residues 174-324 + BIB MM <br />
 
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**[[5mes]], [[5mev]], [[6fs0]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
 
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**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />
 
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*Mcl-1 complex with BH3 domain peptide
 
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**[[2nla]], [[4g35]] – rMcl-1 fragment + NoxaB BH3 domain<br />
 
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**[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
 
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**[[2roc]] - mMcl-1 fragment + Puma BH3 domain<br />
 
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**[[3kz0]] - hMcl-1 + MB7 BH3 domain<br />
 
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**[[3pk1]] – hMcl-1 fragment + hBax BH3 domain<br />
 
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**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
 
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**[[4bpj]], [[4bpi]] - hMcl-1 fragment + Puma BH3 peptide <br />
 
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**[[5c6h]] - hMcl-1 fragment + Mule BH3 peptide <br />
 
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**[[5w89]], [[5w8f]], [[3kj0]], [[3kj1]], [[3kj2]], [[3io9]], [[3d7v]], [[2pqk]], [[5vx2]] - hMcl-1 fragment + BIM BH3 peptide <br />
 
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**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide - NMR <br />
 
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*M11
 
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**[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
 
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**[[2jby]] – MvM11L + Bcl-2 homologous antagonist/killer <br />
 
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**[[3dvu]], [[3bl2]], [[4mi8]] – M11 + Beclin-1 – Murid herpesvirus<br />
 
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*N1L
 
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**[[2i39]] – VvN1L – Vaccinia virus<br />
 
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**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
 
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}}
 
==References==
==References==

Revision as of 08:58, 2 April 2019

NMR structure of bcl-2 1g5m

Drag the structure with the mouse to rotate

References

1. Mee Young Hong; Chapkin, Robert S.; Davidson, Laurie A.; Turner, Nancy D.; Morris, Jeffrey S.; Carroll, Raymond J.; Lupton, Joanne R.. Nutrition & Cancer, 2003, Vol. 46 Issue 1, p44-44, 8p; DOI: NO_DOI; (AN 10719727)

2. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG, Advances In Experimental Medicine And Biology, ISSN: 0065-2598, 1996; Vol. 406, pp. 99-112; PMID: 8910675

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