6m98
From Proteopedia
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<StructureSection load='6m98' size='340' side='right'caption='[[6m98]], [[Resolution|resolution]] 3.21Å' scene=''> | <StructureSection load='6m98' size='340' side='right'caption='[[6m98]], [[Resolution|resolution]] 3.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6m98]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M98 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6m98]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M98 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">COPT1, copt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m98 OCA], [http://pdbe.org/6m98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m98 RCSB], [http://www.ebi.ac.uk/pdbsum/6m98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m98 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m98 OCA], [http://pdbe.org/6m98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m98 RCSB], [http://www.ebi.ac.uk/pdbsum/6m98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m98 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily conserved from fungi to humans, the high-affinity Cu(+) transporter Ctr1 is crucial for both dietary Cu uptake and peripheral distribution, yet the mechanisms for selective permeation of potentially toxic Cu(+) ions across cell membranes are unknown. Here we present X-ray crystal structures of Ctr1 from Salmo salar in both Cu(+)-free and Cu(+)-bound states, revealing a homo-trimeric Cu(+)-selective ion channel-like architecture. Two layers of methionine triads form a selectivity filter, coordinating two bound Cu(+) ions close to the extracellular entrance. These structures, together with Ctr1 functional characterization, provide a high resolution picture to understand Cu(+) import across cellular membranes and suggest therapeutic opportunities for intervention in diseases characterized by inappropriate Cu accumulation. | ||
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| + | X-ray structures of the high-affinity copper transporter Ctr1.,Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P Nat Commun. 2019 Mar 27;10(1):1386. doi: 10.1038/s41467-019-09376-7. PMID:30918258<ref>PMID:30918258</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6m98" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bacillus coli migula 1895]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ren, F]] | [[Category: Ren, F]] | ||
Revision as of 07:56, 10 April 2019
Crystal structure of the high-affinity copper transporter Ctr1 in complex with Cu(I)
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