Aminoacyl tRNA synthetase 3D structures
From Proteopedia
(Difference between revisions)
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**[[4q2y]] – hArgRS (mutant) <br /> | **[[4q2y]] – hArgRS (mutant) <br /> | ||
**[[1bs2]] – yArgRS - yeast<br /> | **[[1bs2]] – yArgRS - yeast<br /> | ||
| - | **[[3gdz]] – | + | **[[3gdz]] – KpArgRS residues 1-106 – ''Klebsiella pneumoniae''<br /> |
**[[1iq0]] – TtArgRS - ''Thermus thermophilus''<br /> | **[[1iq0]] – TtArgRS - ''Thermus thermophilus''<br /> | ||
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**[[3sp1]] - BbCysRS – ''Borrelia burgdorferi''<br /> | **[[3sp1]] - BbCysRS – ''Borrelia burgdorferi''<br /> | ||
**[[3c8z]] – MsCysRS + Cys-SA - ''Mycobacterium smegmatis''<br /> | **[[3c8z]] – MsCysRS + Cys-SA - ''Mycobacterium smegmatis''<br /> | ||
| + | **[[6ujd]] - ElCysRS (mutant) – ''Elizabethkingia'' <br /> | ||
*'''Gln-RS''' | *'''Gln-RS''' | ||
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**[[3tl4]] – yGlnRS tRNA-binding domain<br /> | **[[3tl4]] – yGlnRS tRNA-binding domain<br /> | ||
**[[1nyl]] – EcGlnRS<br /> | **[[1nyl]] – EcGlnRS<br /> | ||
| + | **[[5zdo]] – TtGlnRS<br /> | ||
| + | **[[5zdk]], [[5zdl]] – TtGlnRS + ATP<br /> | ||
**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br /> | **[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br /> | ||
**[[5bnz]] – PaGlnRS – ''Pseudomonas aeruginosa'' <br /> | **[[5bnz]] – PaGlnRS – ''Pseudomonas aeruginosa'' <br /> | ||
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**[[5tgt]] – PaGluRS <br /> | **[[5tgt]] – PaGluRS <br /> | ||
**[[5h4v]] – GluRS – ''Xanthomonas oryzae'' <br /> | **[[5h4v]] – GluRS – ''Xanthomonas oryzae'' <br /> | ||
| + | **[[7k86]] – SmGluRS – ''Stenotrophomonas maltophilia'' <br /> | ||
* ''Glu-RS + small substrates or analogs'' | * ''Glu-RS + small substrates or analogs'' | ||
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**[[1ile]] - TtIleRS<br /> | **[[1ile]] - TtIleRS<br /> | ||
| - | **[[1wny]], [[1udz]] – TtIleRS editing domain<br /> | + | **[[1wny]], [[1udz]] – TtIleRS editing domain 201-381<br /> |
* ''Ile-RS + small substrates or analogs'' | * ''Ile-RS + small substrates or analogs'' | ||
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* ''Ile-RS ternary complex'' | * ''Ile-RS ternary complex'' | ||
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br /> | **[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br /> | ||
| + | **[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br /> | ||
*'''Leu-RS''' | *'''Leu-RS''' | ||
| - | **[[2wfd]] – hLeuRS editing domain<br /> | + | **[[2wfd]] – hLeuRS editing domain 260-509<br /> |
**[[3o0a]], [[3pz0]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br /> | **[[3o0a]], [[3pz0]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br /> | ||
**[[3pz5]] – AaLeuRS hydrolytic domain (mutant)<br /> | **[[3pz5]] – AaLeuRS hydrolytic domain (mutant)<br /> | ||
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* ''Leu-RS + small substrates or analogs'' | * ''Leu-RS + small substrates or analogs'' | ||
| + | **[[6kqy]] - hLeuRS + Leu<br /> | ||
| + | **[[7d5c]] - yLeuRS + inhibitor<br /> | ||
| + | **[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br /> | ||
| + | **[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]] - NgLeuRS (mutant) + intermediate analog<br /> | ||
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br /> | **[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br /> | ||
**[[1h3n]] - TtLeuRS + Leu-SA<br /> | **[[1h3n]] - TtLeuRS + Leu-SA<br /> | ||
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**[[5agi]] - CaLeuRS editing domain (mutant) + AMP derivative<br /> | **[[5agi]] - CaLeuRS editing domain (mutant) + AMP derivative<br /> | ||
**[[5agr]], [[5ags]], [[5agt]] - MtLeuRS editing domain + inhibitor<br /> | **[[5agr]], [[5ags]], [[5agt]] - MtLeuRS editing domain + inhibitor<br /> | ||
| + | **[[7bzj]] - SpLeuRS + inhibitor<br /> | ||
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br /> | **[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br /> | ||
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br /> | **[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br /> | ||
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* ''Leu-RS ternary complex'' | * ''Leu-RS ternary complex'' | ||
| + | **[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br /> | ||
| + | **[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br /> | ||
| + | **[[6kid]] - hLeuRS + ATP + Leu<br /> | ||
**[[4arc]] - EcLeuRS + Leu-tRNA + Leu<br /> | **[[4arc]] - EcLeuRS + Leu-tRNA + Leu<br /> | ||
**[[5omw]] - EcLeuRS + Leu-tRNA + Leu-adenylate analog <br /> | **[[5omw]] - EcLeuRS + Leu-tRNA + Leu-adenylate analog <br /> | ||
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**[[3e9h]], 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br /> | **[[3e9h]], 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br /> | ||
**[[3a74]] - BsLysRS + diadenosine tetraphosphate<br /> | **[[3a74]] - BsLysRS + diadenosine tetraphosphate<br /> | ||
| - | **[[5zh2]], [[5zh3]], [[5zh4]], [[5zh5]], [[4pg3]] - PfLysRS + inhibitor <br /> | + | **[[5zh2]], [[5zh3]], [[5zh4]], [[5zh5]], [[4pg3]], [[6hcv]] - PfLysRS + inhibitor <br /> |
**[[4ycv]] - PfLysRS + cladosporin<br /> | **[[4ycv]] - PfLysRS + cladosporin<br /> | ||
**[[5vl1]] - MuLysRS + Lys – ''Mycobacterium ulcerans''<br /> | **[[5vl1]] - MuLysRS + Lys – ''Mycobacterium ulcerans''<br /> | ||
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**[[5eln]] - CpLysRS + Lys <br /> | **[[5eln]] - CpLysRS + Lys <br /> | ||
**[[4ex5]] - BtLysRS + Lys <br /> | **[[4ex5]] - BtLysRS + Lys <br /> | ||
| + | **[[6wbd]] - SmLysRS + Lys <br /> | ||
*''Lys-RS ternary complexes'' | *''Lys-RS ternary complexes'' | ||
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**[[1e24]] - EcLysRS + Lys + ATP<br /> | **[[1e24]] - EcLysRS + Lys + ATP<br /> | ||
**[[6nrz]] - CtLysRS + Lys + adenosine – ''Chlamydia trachomatis''<br /> | **[[6nrz]] - CtLysRS + Lys + adenosine – ''Chlamydia trachomatis''<br /> | ||
| - | **[[6ns0]] - CtLysRS + Lys + cladosporin<br /> | + | **[[6ns0]], [[6o3f]] - CtLysRS + Lys + cladosporin<br /> |
**[[6bni]] - CpLysRS + Lys + adenine<br /> | **[[6bni]] - CpLysRS + Lys + adenine<br /> | ||
**[[5elo]] - CpLysRS + Lys + cladosporin <br /> | **[[5elo]] - CpLysRS + Lys + cladosporin <br /> | ||
**[[6aqg]] - MuLysRS + Lys + cladosporin <br /> | **[[6aqg]] - MuLysRS + Lys + cladosporin <br /> | ||
| + | **[[6agt]], [[6ka6]], [[6kab]], [[6kbf]], [[6kcn]], [[6kct]] - PfLysRS + Lys + cladosporin derivative<br /> | ||
| + | **[[7bt5]] - PfLysRS + Lys + drug<br /> | ||
| + | **[[6hcu]], [[6hcw]] - PfLysRS + Lys + inhibitor<br /> | ||
**[[6aqh]] - LysRS + Lys + cladosporin – ''Mycobacterium thermoresistibile''<br /> | **[[6aqh]] - LysRS + Lys + cladosporin – ''Mycobacterium thermoresistibile''<br /> | ||
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**[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br /> | **[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br /> | ||
**[[1qqt]], [[3h9c]] - EcMetRS residues 2-552<br /> | **[[1qqt]], [[3h9c]] - EcMetRS residues 2-552<br /> | ||
| - | **[[3h97]] – EcMetRS residues 2-548 (mutant) <br /> | + | **[[3h97]], [[6spp]] – EcMetRS residues 2-548 (mutant) <br /> |
**[[1a8h]] – TtMetRS<br /> | **[[1a8h]] – TtMetRS<br /> | ||
**[[2d54]], [[2d5b]] – TtMetRS (mutant) <br /> | **[[2d54]], [[2d5b]] – TtMetRS (mutant) <br /> | ||
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**[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br /> | **[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br /> | ||
**[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br /> | **[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br /> | ||
| - | **[[1f4l]] - EcMetRS residues 1-551 + Met<br /> | + | **[[1f4l]], [[6spo]] - EcMetRS residues 1-551 + Met<br /> |
| + | **[[6spq]] - EcMetRS (mutant) + Met<br /> | ||
| + | **[[6spn]] - EcMetRS + beta-Met<br /> | ||
| + | **[[6spr]] - EcMetRS (mutant) + beta-Met<br /> | ||
**[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br /> | **[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br /> | ||
**[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br /> | **[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br /> | ||
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**[[5k0s]], [[5k0t]] – MetRS + inhibitor – ''Brucella suis''<br /> | **[[5k0s]], [[5k0t]] – MetRS + inhibitor – ''Brucella suis''<br /> | ||
**[[4zt2]], [[4zt3]], [[4zt4]], [[4zt5]], [[4zt6]], [[4zt7]], [[4mvw]], [[4mvx]], [[4mvy]], [[4mw0]], [[4mw1]], [[4mw2]], [[4mw4]], [[4mw5]], [[4mw6]], [[4mw7]], [[4mw9]], [[4mwb]], [[4mwc]], [[4mwd]], [[4mwe]] - TbMetRS residues 237-773 (mutant) + inhibitor – ''Trypanosoma brucei''<br /> | **[[4zt2]], [[4zt3]], [[4zt4]], [[4zt5]], [[4zt6]], [[4zt7]], [[4mvw]], [[4mvx]], [[4mvy]], [[4mw0]], [[4mw1]], [[4mw2]], [[4mw4]], [[4mw5]], [[4mw6]], [[4mw7]], [[4mw9]], [[4mwb]], [[4mwc]], [[4mwd]], [[4mwe]] - TbMetRS residues 237-773 (mutant) + inhibitor – ''Trypanosoma brucei''<br /> | ||
| + | **[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br /> | ||
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br /> | **[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br /> | ||
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**[[5tew]] - NgTrpRS + Trp<br /> | **[[5tew]] - NgTrpRS + Trp<br /> | ||
**[[4j75]] - PfTrpRS + Trp-AMP<br /> | **[[4j75]] - PfTrpRS + Trp-AMP<br /> | ||
| + | **[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br /> | ||
*''Trp-RS ternary complex'' | *''Trp-RS ternary complex'' | ||
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**[[1x8x]] – EcTyrRS + Tyr<br /> | **[[1x8x]] – EcTyrRS + Tyr<br /> | ||
**[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br /> | **[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br /> | ||
| + | **[[6wn2]], [[6wrn]], [[6wrt]] - EcTyrRS (mutant) + Tyr derivative<br /> | ||
**[[4oud]] - EcTyrRS + bi-Phe <br /> | **[[4oud]] - EcTyrRS + bi-Phe <br /> | ||
| + | **[[6i5y]] - EcTyrRS + Tyr-SA <br /> | ||
| + | **[[6hb5]] - EcTyrRS + Tyr-SC <br /> | ||
| + | **[[6hb6]], [[6hb7]] - EcTyrRS + Tyr-SU <br /> | ||
| + | **[[7ap3]] - EcTyrRS + inhibitor<br /> | ||
**[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus<br /> | **[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus<br /> | ||
**[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br /> | **[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br /> | ||
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**[[1h3f]]- TtTyrRS + Tyr-ol<br /> | **[[1h3f]]- TtTyrRS + Tyr-ol<br /> | ||
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br /> | **[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br /> | ||
| + | **[[6otj]] – NgTyrRS + Tyr<br /> | ||
* ''Tyr-RS + tRNA'' | * ''Tyr-RS + tRNA'' | ||
Revision as of 09:13, 16 March 2021
3D Structures of Aminoacyl tRNA Synthetase
Updated on 16-March-2021
