6bza

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Current revision (14:25, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6bza' size='340' side='right'caption='[[6bza]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6bza' size='340' side='right'caption='[[6bza]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bza]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psef5 Psef5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bza]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_protegens_Pf-5 Pseudomonas protegens Pf-5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13X:BENZENE-1,3,5-TRIOL'>13X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pltM, PFL_2784 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220664 PSEF5])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13X:BENZENE-1,3,5-TRIOL'>13X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bza OCA], [https://pdbe.org/6bza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bza RCSB], [https://www.ebi.ac.uk/pdbsum/6bza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bza ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bza OCA], [http://pdbe.org/6bza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bza RCSB], [http://www.ebi.ac.uk/pdbsum/6bza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bza ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4KCZ3_PSEF5 Q4KCZ3_PSEF5]
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Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.
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Unusual substrate and halide versatility of phenolic halogenase PltM.,Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV Nat Commun. 2019 Mar 19;10(1):1255. doi: 10.1038/s41467-019-09215-9. PMID:30890712<ref>PMID:30890712</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6bza" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alkylhalidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Psef5]]
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[[Category: Pseudomonas protegens Pf-5]]
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[[Category: Garneau-Tsodikova, S]]
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[[Category: Garneau-Tsodikova S]]
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[[Category: Pang, A H]]
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[[Category: Pang AH]]
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[[Category: Tsodikov, O V]]
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[[Category: Tsodikov OV]]
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[[Category: Brominase]]
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[[Category: Chlorinase]]
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[[Category: Flavoprotein]]
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[[Category: Halogenase]]
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[[Category: Iodinase]]
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Current revision

Crystal structure of halogenase PltM in complex with phloroglucinol and FAD

PDB ID 6bza

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