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4lee

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<StructureSection load='4lee' size='340' side='right'caption='[[4lee]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4lee' size='340' side='right'caption='[[4lee]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LEE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LEE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4le8|4le8]], [[4leb|4leb]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lee OCA], [https://pdbe.org/4lee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lee RCSB], [https://www.ebi.ac.uk/pdbsum/4lee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lee ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALD8, ALS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lee OCA], [http://pdbe.org/4lee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lee RCSB], [http://www.ebi.ac.uk/pdbsum/4lee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lee ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALS3_CANAX ALS3_CANAX]] Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells (By similarity).
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[https://www.uniprot.org/uniprot/ALS3_CANAL ALS3_CANAL] Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.<ref>PMID:15128742</ref> <ref>PMID:15256583</ref> <ref>PMID:16839200</ref> <ref>PMID:17510860</ref> <ref>PMID:18635358</ref> <ref>PMID:22321066</ref> <ref>PMID:22429754</ref> <ref>PMID:22544909</ref> <ref>PMID:23630968</ref> <ref>PMID:24152214</ref> <ref>PMID:24736223</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cota, E]]
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[[Category: Cota E]]
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[[Category: Garnett, J A]]
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[[Category: Garnett JA]]
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[[Category: Lin, J]]
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[[Category: Lin J]]
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[[Category: Adhesin]]
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[[Category: Biofilm formation]]
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[[Category: Cell adhesion]]
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[[Category: Cell surface]]
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[[Category: Cellular adhesion]]
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[[Category: Peptide]]
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[[Category: Peptide binding protein]]
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Revision as of 04:32, 30 September 2022

Structure of the Als3 adhesin from Candida albicans, residues 1-313 (mature sequence), triple mutant in the binding cavity: K59M, A116V, Y301F

PDB ID 4lee

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