4m8y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4m8y' size='340' side='right'caption='[[4m8y]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
<StructureSection load='4m8y' size='340' side='right'caption='[[4m8y]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rkf|2rkf]], [[2rkg|2rkg]], [[4m8x|4m8x]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [https://pdbe.org/4m8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [https://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://pdbe.org/4m8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q90JJ9_9HIV1 Q90JJ9_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 26: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: HIV-1 retropepsin]]
+
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Brynda, J]]
+
[[Category: Brynda J]]
-
[[Category: Konvalinka, J]]
+
[[Category: Grantz saskova K]]
-
[[Category: Kozisek, M]]
+
[[Category: Konvalinka J]]
-
[[Category: Rezacova, P]]
+
[[Category: Kozisek M]]
-
[[Category: Saskova, K Grantz]]
+
[[Category: Rezacova P]]
-
[[Category: Amino acid insertion]]
+
-
[[Category: Aspartic protease]]
+
-
[[Category: Hiv-1 protease]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+

Revision as of 11:03, 21 December 2022

GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions

PDB ID 4m8y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4m8y"
Personal tools