User:Emily Leiderman/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Introduction == | == Introduction == | ||
| + | The reversible acetylation of lysine residues of histone has been proven to play an important role in the regulation of heterochromatin (inactive) and euchromatin (active). The role of the protein Histone Acetyltransferase is to transfer an acetyl group from <scene name='81/811098/Acetyl_coa/5'>Acetyl-CoA</scene> to a lysine group found on a histone. This results in an increase in gene activity as the addition of acetyl groups to histones results in the formation of euchromatin. In this study we analyzed the structure and function of the HAT1 gene that’s derived from Saccharomyces cerevisiae. Analysis of the various binding sites and interaction mechanisms involved in the acetylation process in addition to the initial Acetyl CoA binding mechanism <ref>DOI:10.1093/nar/gkx545</ref> . | ||
| + | |||
== Structure == | == Structure == | ||
Revision as of 20:33, 7 April 2019
Histone Acetyltransferase HAT1
| |||||||||||
References
- ↑ Agudelo Garcia PA, Hoover ME, Zhang P, Nagarajan P, Freitas MA, Parthun MR. Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly. Nucleic Acids Res. 2017 Sep 19;45(16):9319-9335. doi: 10.1093/nar/gkx545. PMID:28666361 doi:http://dx.doi.org/10.1093/nar/gkx545
