6r8q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT== | |
| - | + | <StructureSection load='6r8q' size='340' side='right'caption='[[6r8q]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r8q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R8Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JV5:~{N}-(1~{H}-benzotriazol-5-yl)-2-(2-methylphenoxy)ethanamide'>JV5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Wnt_protein]_O-palmitoleoyl-L-serine_hydrolase [Wnt protein] O-palmitoleoyl-L-serine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.98 3.1.1.98] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8q OCA], [http://pdbe.org/6r8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r8q RCSB], [http://www.ebi.ac.uk/pdbsum/6r8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOTUM_HUMAN NOTUM_HUMAN]] May deacetylate GlcNAc residues on cell surface glycans. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jones, E Y]] | ||
| + | [[Category: Ruza, R R]] | ||
[[Category: Vecchia, L]] | [[Category: Vecchia, L]] | ||
| - | [[Category: | + | [[Category: Crystallographic fragment screen]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Notum inhibitor]] | ||
| + | [[Category: Wnt signalling]] | ||
Revision as of 11:28, 10 May 2019
STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT
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