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6i6m
From Proteopedia
(Difference between revisions)
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<StructureSection load='6i6m' size='340' side='right'caption='[[6i6m]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='6i6m' size='340' side='right'caption='[[6i6m]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6i6m]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6i6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I6M FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6m OCA], [https://pdbe.org/6i6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i6m RCSB], [https://www.ebi.ac.uk/pdbsum/6i6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6m ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SOMT1_PAPSO SOMT1_PAPSO] Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:22535422, PubMed:22653730, PubMed:29610307). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (PubMed:22535422, PubMed:22653730). Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine (PubMed:22535422). Can convert (S)-norreticuline to (S)-norcodamine (PubMed:22535422). Can convert (S)-reticuline to (S)-codamine (PubMed:22535422). Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline (PubMed:22535422).<ref>PMID:22535422</ref> <ref>PMID:22653730</ref> <ref>PMID:29610307</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Opium poppy]] | ||
| - | [[Category: Cabry, M P]] | ||
| - | [[Category: Davies, G J]] | ||
| - | [[Category: Graham, I A]] | ||
| - | [[Category: Li, Y]] | ||
| - | [[Category: Offen, W A]] | ||
| - | [[Category: Saleh, P]] | ||
| - | [[Category: Winzer, T]] | ||
| - | [[Category: Benzylisoquinoline alkaloid]] | ||
| - | [[Category: Noscapine]] | ||
[[Category: Papaver somniferum]] | [[Category: Papaver somniferum]] | ||
| - | [[Category: | + | [[Category: Cabry MP]] |
| - | [[Category: | + | [[Category: Davies GJ]] |
| - | [[Category: | + | [[Category: Graham IA]] |
| - | [[Category: | + | [[Category: Li Y]] |
| + | [[Category: Offen WA]] | ||
| + | [[Category: Saleh P]] | ||
| + | [[Category: Winzer T]] | ||
Current revision
Papaver somniferum O-methyltransferase 1
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Categories: Large Structures | Papaver somniferum | Cabry MP | Davies GJ | Graham IA | Li Y | Offen WA | Saleh P | Winzer T
