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4miy

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<StructureSection load='4miy' size='340' side='right'caption='[[4miy]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
<StructureSection load='4miy' size='340' side='right'caption='[[4miy]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4miy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Laccb Laccb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MIY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4miy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei_BL23 Lacticaseibacillus casei BL23]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MIY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cea|3cea]], [[3mz0|3mz0]], [[3nt4|3nt4]], [[3ntq|3ntq]], [[4mie|4mie]], [[4min|4min]], [[4mio|4mio]], [[4mjl|4mjl]], [[4mkx|4mkx]], [[4mkz|4mkz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4miy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4miy OCA], [https://pdbe.org/4miy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4miy RCSB], [https://www.ebi.ac.uk/pdbsum/4miy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4miy ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">idh, iolG, iolG1, LCABL_02210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=543734 LACCB])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol_2-dehydrogenase Inositol 2-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.18 1.1.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4miy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4miy OCA], [http://pdbe.org/4miy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4miy RCSB], [http://www.ebi.ac.uk/pdbsum/4miy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4miy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B3W8L3_LACCB B3W8L3_LACCB]] Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.[HAMAP-Rule:MF_01671]
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[https://www.uniprot.org/uniprot/A0A0J9X1Y2_LACCB A0A0J9X1Y2_LACCB] Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.[HAMAP-Rule:MF_01671]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Inositol 2-dehydrogenase]]
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[[Category: Lacticaseibacillus casei BL23]]
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[[Category: Laccb]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bertwistle, D]]
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[[Category: Bertwistle D]]
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[[Category: Palmer, D R.J]]
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[[Category: Palmer DRJ]]
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[[Category: Sanders, D A.R]]
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[[Category: Sanders DAR]]
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[[Category: Dehydrogenase]]
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[[Category: Dehydrogenate]]
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[[Category: Myo-inositol binding]]
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[[Category: Nad]]
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[[Category: Nad binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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[[Category: Sugar alcohol dehydrogenase]]
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Revision as of 09:40, 28 December 2022

Crystal Structure of myo-inositol dehydrogenase from Lactobacillus casei in complex with NAD and myo-inositol

PDB ID 4miy

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