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4n6m

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<StructureSection load='4n6m' size='340' side='right'caption='[[4n6m]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4n6m' size='340' side='right'caption='[[4n6m]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N6M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N6M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n6l|4n6l]], [[4n6n|4n6n]], [[4n6o|4n6o]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6m OCA], [https://pdbe.org/4n6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n6m RCSB], [https://www.ebi.ac.uk/pdbsum/4n6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n6m ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CST6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6m OCA], [http://pdbe.org/4n6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n6m RCSB], [http://www.ebi.ac.uk/pdbsum/4n6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n6m ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYTM_HUMAN CYTM_HUMAN]] Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
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[https://www.uniprot.org/uniprot/CYTM_HUMAN CYTM_HUMAN] Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brandstetter, H]]
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[[Category: Brandstetter H]]
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[[Category: Dall, E]]
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[[Category: Dall E]]
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[[Category: Asparaginyl endopeptidase]]
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[[Category: Cancer]]
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[[Category: Cathepsin]]
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[[Category: Cystatin fold]]
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[[Category: Cysteine protease inhibitor]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Legumain]]
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[[Category: Papain]]
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[[Category: Protease inhibitor]]
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[[Category: Reactive center loop]]
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Revision as of 08:12, 11 January 2023

Crystal structure of human cystatin E/M produced in LEXSY

PDB ID 4n6m

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