3c6e

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{{STRUCTURE_3c6e| PDB=3c6e | SCENE= }}
{{STRUCTURE_3c6e| PDB=3c6e | SCENE= }}
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'''Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH'''
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===Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH===
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==Overview==
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Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo-electron microscopy density of immature virus at neutral pH. The pr peptide beta-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.
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==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:30:25 2008''

Revision as of 16:30, 28 July 2008

Image:3c6e.png

Template:STRUCTURE 3c6e

Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH

Template:ABSTRACT PUBMED 18369147

About this Structure

3C6E is a Protein complex structure of sequences from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

The flavivirus precursor membrane-envelope protein complex: structure and maturation., Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG, Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147

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