3caj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3caj", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3caj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3caj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3caj| PDB=3caj | SCENE= }}
{{STRUCTURE_3caj| PDB=3caj | SCENE= }}
-
'''Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide'''
+
===Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide===
-
==Overview==
+
<!--
-
Ethoxzolamide, an almost forgotten inhibitor of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), is the only classical inhibitor whose structure in adduct with any isoform was not reported yet. We report here the inhibition data of this molecule with the 12 catalytically active mammalian isozymes (CA I-CA XIV) and the X-ray crystal structure with the cytosolic, ubiquitous isoform CA II. These data are presumably useful for the design of novel CA inhibitors, targeting various CA isozymes, considering that ethoxzolamide was already the lead molecule to obtain the second generation inhibitors, dorzolamide and brinzolamide, clinically used antiglaucoma agents with topical action, as well as various other investigational agents.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18359629}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18359629 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18359629}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors., Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G, Bioorg Med Chem Lett. 2008 Mar 18;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18359629 18359629]
Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors., Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G, Bioorg Med Chem Lett. 2008 Mar 18;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18359629 18359629]
 +
 +
Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors., Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN, Protein Sci. 1994 Jan;3(1):118-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8142888 8142888]
 +
 +
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination., Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW, Protein Sci. 1998 Mar;7(3):556-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9541386 9541386]
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 33: Line 41:
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
[[Category: Zinc]]
[[Category: Zinc]]
 +
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:53:48 2008''

Revision as of 04:53, 28 July 2008

Image:3caj.png

Template:STRUCTURE 3caj

Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide

Template:ABSTRACT PUBMED 18359629

About this Structure

3CAJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors., Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G, Bioorg Med Chem Lett. 2008 Mar 18;. PMID:18359629

Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors., Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN, Protein Sci. 1994 Jan;3(1):118-25. PMID:8142888

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination., Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW, Protein Sci. 1998 Mar;7(3):556-63. PMID:9541386

Page seeded by OCA on Mon Jul 28 07:53:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3caj"
Personal tools