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| | <StructureSection load='6hs3' size='340' side='right'caption='[[6hs3]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='6hs3' size='340' side='right'caption='[[6hs3]], [[Resolution|resolution]] 2.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6hs3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6flx 6flx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HS3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6hs3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6flx 6flx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HS3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lptB_3, lptB, BOC42_17415, CXQ84_18695, DP46_1122, DP49_575, ERS012350_00705 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hs3 OCA], [http://pdbe.org/6hs3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hs3 RCSB], [http://www.ebi.ac.uk/pdbsum/6hs3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hs3 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hs3 OCA], [https://pdbe.org/6hs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hs3 RCSB], [https://www.ebi.ac.uk/pdbsum/6hs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hs3 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q63XK6_BURPS Q63XK6_BURPS] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus pseudomallei whitmore 1913]] | |
| - | [[Category: Large Structures]] | |
| - | [[Category: Dawson, A]] | |
| - | [[Category: Hunter, W N]] | |
| - | [[Category: Pankov, G]] | |
| - | [[Category: Abc transporter]] | |
| - | [[Category: Atp-binding protein]] | |
| | [[Category: Burkholderia pseudomallei]] | | [[Category: Burkholderia pseudomallei]] |
| - | [[Category: Cytosolic protein]] | + | [[Category: Large Structures]] |
| - | [[Category: Transport protein]] | + | [[Category: Dawson A]] |
| | + | [[Category: Hunter WN]] |
| | + | [[Category: Pankov G]] |
| Structural highlights
Function
Q63XK6_BURPS
Publication Abstract from PubMed
The thick outer membrane (OM) of Gram-negative bacteria performs an important protective role against hostile environments, supports cell integrity, and contributes to surface adhesion and in some cases also to virulence. A major component of the OM is lipopolysaccharide (LPS), a complex glycolipid attached to a core containing fatty-acyl chains. The assembly and transport of lipid A, the membrane anchor for LPS, to the OM begins when a heteromeric LptB2FG protein complex extracts lipid A from the outer leaflet of the inner membrane. This process requires energy, and upon hydrolysis of ATP one component of the heteromeric assembly, LptB, triggers a conformational change in LptFG in support of lipid A transport. A structure of LptB from the intracellular pathogen Burkholderia pseudomallei is reported here. LptB forms a dimer that displays a relatively fixed structure irrespective of whether it is in complex with LptFG or in isolation. Highly conserved sequence and structural features are discussed that allow LptB to fuel the transport of lipid A.
The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei.,Pankov G, Dawson A, Hunter WN Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):227-232. doi:, 10.1107/S2053230X19001778. Epub 2019 Mar 13. PMID:30950822[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pankov G, Dawson A, Hunter WN. The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei. Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):227-232. doi:, 10.1107/S2053230X19001778. Epub 2019 Mar 13. PMID:30950822 doi:http://dx.doi.org/10.1107/S2053230X19001778
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