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4pk6

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Current revision (13:09, 1 February 2023) (edit) (undo)
 
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<StructureSection load='4pk6' size='340' side='right'caption='[[4pk6]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
<StructureSection load='4pk6' size='340' side='right'caption='[[4pk6]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PK6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PK6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PKL:N-[2-(3-CHLOROPHENYL)ETHYL]-3-(4-METHYLPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBOXAMIDE'>PKL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PKL:N-[2-(3-CHLOROPHENYL)ETHYL]-3-(4-METHYLPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBOXAMIDE'>PKL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pk5|4pk5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk6 OCA], [https://pdbe.org/4pk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pk6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk6 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDO1, IDO, INDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk6 OCA], [http://pdbe.org/4pk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN]] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
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[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ishii, T]]
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[[Category: Ishii T]]
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[[Category: Kamioka, S]]
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[[Category: Kamioka S]]
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[[Category: Kohno, T]]
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[[Category: Kohno T]]
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[[Category: Tojo, S]]
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[[Category: Tojo S]]
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[[Category: 3-dioxygenagse 1]]
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[[Category: Imidazothiazole]]
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[[Category: Indoleamine 2]]
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[[Category: Induced fit]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structure based drug discovery]]
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Current revision

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with imidazothiazole derivative

PDB ID 4pk6

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