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4op3

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<StructureSection load='4op3' size='340' side='right'caption='[[4op3]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
<StructureSection load='4op3' size='340' side='right'caption='[[4op3]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4op3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OP3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4op3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OP3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UY:(2S)-2-{6-[(6-AMINOPYRIDIN-3-YL)SULFONYL]-2-(PHENYLAMINO)-2,3-BIPYRIDIN-5-YL}-1,1,1-TRIFLUOROPROPAN-2-OL'>2UY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UY:(2S)-2-{6-[(6-AMINOPYRIDIN-3-YL)SULFONYL]-2-(PHENYLAMINO)-2,3-BIPYRIDIN-5-YL}-1,1,1-TRIFLUOROPROPAN-2-OL'>2UY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ohk|4ohk]], [[4ohm|4ohm]], [[4oho|4oho]], [[4ohp|4ohp]], [[4olh|4olh]], [[4op1|4op1]], [[4op2|4op2]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4op3 OCA], [https://pdbe.org/4op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4op3 RCSB], [https://www.ebi.ac.uk/pdbsum/4op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4op3 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCKR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4op3 OCA], [http://pdbe.org/4op3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4op3 RCSB], [http://www.ebi.ac.uk/pdbsum/4op3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4op3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
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[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chmait, S]]
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[[Category: Chmait S]]
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[[Category: Jordan, S R]]
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[[Category: Jordan SR]]
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[[Category: Binds to and inhibits glucokinase]]
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[[Category: Carbohydrate binding protein-inhibitor complex]]
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[[Category: Glucokinase]]
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[[Category: Liver]]
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[[Category: Sis domain containing protein]]
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Revision as of 07:37, 25 January 2023

Human GKRP bound to AMG-5112 and Sorbitol-6-phosphate

PDB ID 4op3

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