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4on3

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Current revision (07:34, 25 January 2023) (edit) (undo)
 
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<StructureSection load='4on3' size='340' side='right'caption='[[4on3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4on3' size='340' side='right'caption='[[4on3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4on3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ON3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ON3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4on3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ON3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ON3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNX10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4on3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4on3 OCA], [https://pdbe.org/4on3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4on3 RCSB], [https://www.ebi.ac.uk/pdbsum/4on3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4on3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4on3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4on3 OCA], [http://pdbe.org/4on3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4on3 RCSB], [http://www.ebi.ac.uk/pdbsum/4on3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4on3 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Autosomal recessive malignant osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22499339</ref> <ref>PMID:23123320</ref> <ref>PMID:23280965</ref>
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[https://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN] Autosomal recessive malignant osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22499339</ref> <ref>PMID:23123320</ref> <ref>PMID:23280965</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<ref>PMID:17012226</ref> <ref>PMID:21844891</ref> <ref>PMID:22499339</ref>
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[https://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN] Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<ref>PMID:17012226</ref> <ref>PMID:21844891</ref> <ref>PMID:22499339</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Sorting nexin|Sorting nexin]]
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Liu, J]]
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[[Category: Liu J]]
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[[Category: Wang, Q]]
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[[Category: Wang Q]]
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[[Category: Xu, J]]
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[[Category: Xu J]]
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[[Category: Xu, T]]
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[[Category: Xu T]]
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[[Category: Phox-homology domain]]
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[[Category: Protein transport]]
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[[Category: Sorting nexin]]
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Current revision

Crystal structure of human sorting nexin 10 (SNX10)

PDB ID 4on3

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OCA

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