4ov1
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ov1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ov1 OCA], [http://pdbe.org/4ov1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ov1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ov1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ov1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ov1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ov1 OCA], [http://pdbe.org/4ov1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ov1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ov1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ov1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Rhodopseudomonas palustris HaA2 contains a gene, RPB3630, encoding a ferredoxin, HaPuxC, with an atypical CXXHXXC(X)nCP iron-sulfur cluster-binding motif. The ferredoxin gene is associated with a cytochrome P450 (CYP) monooxygenase-encoding gene, CYP194A3, an arrangement which is conserved in several strains of bacteria. Similar ferredoxin genes are found in other bacteria, such as Mycobacterium tuberculosis, where they are also associated with CYP genes. The crystal structure of HaPuxC has been solved at 2.3 A resolution. The overall fold of this [3Fe-4S] cluster-containing ferredoxin is similar to other [3Fe-4S] and [4Fe-4S] species, with the loop around the iron-sulfur cluster more closely resembling those of [3Fe-4S] ferredoxins. The side chain of His17 from the cluster-binding motif in HaPuxC points away from the vacant site of the cluster and interacts with Glu61 and one of the sulfide ions of the cluster. This is the first cytochrome P450 electron-transfer partner of this type to be structurally characterized and will provide a better understanding of the electron-transfer processes between these ferredoxins and their CYP enzymes. | ||
+ | |||
+ | The structure of a novel electron-transfer ferredoxin from Rhodopseudomonas palustris HaA2 which contains a histidine residue in its iron-sulfur cluster-binding motif.,Zhang T, Zhang A, Bell SG, Wong LL, Zhou W Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1453-64. doi:, 10.1107/S139900471400474X. Epub 2014 Apr 30. PMID:24816113<ref>PMID:24816113</ref> | ||
+ | |||
+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
+ | <div class="pdbe-citations 4ov1" style="background-color:#fffaf0;"></div> | ||
+ | == References == | ||
+ | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> |
Revision as of 10:06, 25 December 2019
The crystal structure of a novel electron transfer ferredoxin from R. palustris HaA2
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