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4pt5

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<StructureSection load='4pt5' size='340' side='right'caption='[[4pt5]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='4pt5' size='340' side='right'caption='[[4pt5]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PT5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PT5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pt5 OCA], [https://pdbe.org/4pt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pt5 RCSB], [https://www.ebi.ac.uk/pdbsum/4pt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pt5 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pt5 OCA], [http://pdbe.org/4pt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pt5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pt5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/K4LC41_9BETC K4LC41_9BETC]] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).[SAAS:SAAS014829_004_014545] Nsp9 is a ssRNA-binding protein (By similarity).[SAAS:SAAS014829_004_001449]
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[https://www.uniprot.org/uniprot/K4LC41_MERS K4LC41_MERS]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human betacoronavirus 2c emc/2012]]
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[[Category: Human betacoronavirus 2c EMC/2012]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Papain]]
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[[Category: Johnson ME]]
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[[Category: Johnson, M E]]
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[[Category: Lee H]]
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[[Category: Lee, H]]
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[[Category: Lei H]]
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[[Category: Lei, H]]
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[[Category: Santarsiero BD]]
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[[Category: Santarsiero, B D]]
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[[Category: Hydrolase]]
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[[Category: Mers-cov]]
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[[Category: Protease]]
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Revision as of 07:29, 8 February 2023

Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus

PDB ID 4pt5

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