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Calmodulin

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</StructureSection>
</StructureSection>
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== 3D Structures of Calmodulin ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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* Native CaM
 
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**[[1prw]], [[1deg]] – bCaM - bovine<br />
 
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**[[1up5]] – cCaM – chicken<br />
 
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**[[1clm]], [[1osa]], [[1exr]], [[5e1p]], [[5e1n]], [[5e1k]] – PtCaM - ''Paramecium tetraurelia''<br />
 
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**[[3cln]] – rCaM - rat<br />
 
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**[[1x02]], [[1dmo]] – XlCaM – NMR - ''Xenopus laevis''<br />
 
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**[[2k61]], [[2k0e]] – hCaM – NMR - human<br />
 
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**[[1y6w]], [[1cll]], [[4bw8]] - hCaM<br />
 
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**[[4cln]] – DmCaM - ''Drosophila melanogaster''<br />
 
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**[[1rfj]] – CaM – potato<br />
 
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**[[1ooj]] – CaM – ''Caenorhabditis elegans''<br />
 
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**[[4hex]] – mCaM – mouse<br />
 
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**[[5a2h]] – AtCaM-7 – ''Arabidopsis thaliana''<br />
 
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* Mutant CaM
 
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**[[1ahr]], [[2m3s]] – cCaM (mutant)<br />
 
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**[[2k0j]], [[1sw8]], [[5ggm]], [[5tp5]] – hCaM (mutant) – NMR<br />
 
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* apo CaM
 
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**[[1lkj]] – yapoCaM – NMR -yeast<br />
 
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**[[1cfc]], [[1cfd]] - XlapoCaM – NMR<br />
 
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**[[1qx5]] – rapoCaM – rat<br />
 
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* CaM N-terminal
 
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**[[2i08]], [[5dsu]] - hCaM N-terminal (mutant)<br />
 
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**[[1j7o]], [[1j7p]] - hCaM N-terminal – NMR<br />
 
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**[[1f70]] - XlCaM N-terminal – NMR <br />
 
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**[[2ro8]], [[2roa]] - sCaM N-terminal+Ca – NMR - soybean<br />
 
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**[[2ro9]], [[2rob]] - sCaM C-terminal+Ca – NMR<br />
 
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**[[3ifk]], [[3b32]] – rCaM N-terminal <br />
 
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**[[1f54]], [[1f55]] – yapoCaM N-terminal – NMR<br />
 
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* CaM C-terminal
 
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**[[1f71]] - XlCaM C-terminal – NMR<br />
 
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**[[1cmg]] – bCaM C-terminal – NMR<br />
 
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**[[1fw4]] - bCaM C-terminal<br />
 
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**[[4rjd]] – rCaM<br />
 
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**[[1cmf]] – bapoCaM C-terminal – NMR<br />
 
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**[[2hf5]] - hCaM EF2 EF3 – NMR<br />
 
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**[[2lqp]] - hCaM EF3 EF4 – NMR<br />
 
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**[[2kxw]] – PtapoCaM + IQ motif of NAV1.2 – NMR<br />
 
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**[[2m5e]] – PtCaM + Na channel protein<br />
 
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**[[2kz2]], [[4bya]] – CaM (mutant) – chicken - NMR<br >
 
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**[[2rrt]] – XlCaM (mutant) - NMR<br />
 
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* CaM+ cations (non calcium)
 
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**[[2ksz]] – sCaM N-terminal+Mg – NMR <br />
 
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**[[1ak8]] - bCaM N-terminal+Ce – NMR<br />
 
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**[[2pq3]] – rCaM+Zn<br />
 
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**[[2v01]] – hCaM+Pb<br />
 
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**[[2v02]] – hCaM+Ba<br />
 
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**[[4bw7]] – hCaM + Sr<br />
 
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**[[3uct]] – hCaM + Mn + Zn<br />
 
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**[[3ucw]] - hCaM N-terminal + Mg<br />
 
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**[[3ucy]] - hCaM N-terminal + Mg + Zn<br />
 
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**[[1n0y]] – PtCaM+Pb <br />
 
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**[[2lhh]] – yCaM + Ca - NMR
 
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* CaM small molecule complexes
 
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**[[3if7]] – bCaM+sphingosylphosphorylcholine<br />
 
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**[[1qiv]], [[1qiw]] – bCaM+DPDv<br />
 
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**[[1a29]], [[1lin]] – bCaM+trifluoperazine<br />
 
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**[[1ctr]] - hCaM+trifluoperazine <br />
 
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**[[2kug]], [[2kuh]] - hCaM N-terminal EF1 EF2+halothane – NMR<br />
 
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**[[2kdu]] – XlCaM+MUNC13-1 – NMR<br />
 
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**[[1mux]] – XlCaM+W-7 – NMR<br />
 
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**[[1xa5]] – bCaM+KAR-2<br />
 
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* CaM complexed with protein CBD domains
 
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**[[3gp2]] – cCaM+CaM kinase II δ chain<br />
 
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**[[2dfs]] – cCaM+myosin 5A<br />
 
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**[[2o5g]] – cCaM+ myosin light chain kinase peptide<br />
 
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**[[2bcx]] – cCaM+ryanodine receptor 1 peptide<br />
 
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**[[3gof]], [[2o60]] – cCaM+nitric oxide synthase CBD<br />
 
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**[[1niw]] - rCaM+nitric oxide synthase CBD <br />
 
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**[[2hqw]] - rCaM+glutamate receptor peptide<br />
 
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**[[3bxk]], [[3bxl]], [[4ehq]], [[4j9y]], [[4j9z]] – rCaM+ calcium channel peptide<br />
 
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**[[1g4y]], [[3sjq]], [[4g27]], [[4g28]], [[4qnh]] - rCaM+ potassium channel CBD<br />
 
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**[[2ygg]] – rCaM + Na/H exchanger CBD<br />
 
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**[[2mgu]] – rCaM + HIV-1 matrix protein CBD – NMR<br />
 
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**[[1qx7]] – rapoCaM+potassium channel peptide<br />
 
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**[[5hit]] – cCaM + potassium channel peptide<br />
 
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**[[5dbr]] – hCaM + sodium channel peptide<br />
 
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**[[4gow]], [[4umo]], [[4v0c]] – hCaM + potassium channel peptide<br />
 
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**[[3hr4]], [[2ll6]], [[2ll7]], [[5tp6]] - hCaM+nitric oxide synthase CBD <br />
 
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**[[1yr5]], [[1wrz]], [[2y4v]] – hCaM+death-associated protein kinase 1 (DAP)<br />
 
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**[[2l7l]] - hCaM+ CaM-dependent protein kinase 1 CBD<br />
 
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**[[6hcs]] - hCaM+ CaM-dependent protein kinase 2 peptide<br />
 
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**[[2m0j]], [[2m0k]] - hCaM+olfactory channel peptide<br />
 
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**[[2kne]] – hCaM+PMCA C-terminal CBD<br />
 
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**[[4upu]] - hCaM+ IP3 3-K CBD<br />
 
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**[[3ewt]], [[3ewv]] – hCaM+TNFR fragment<br />
 
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**[[2w73]], [[2jzi]], [[2r28]] – hCaM+Ser/Thr phosphatase CBD<br />
 
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**[[3bya]] – hCaM+glutamate receptor peptide<br />
 
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**[[3g43]], [[2vay]], [[2f3y]], [[2f3z]], [[2be6]], [[2lqc]], [[3oxq]] – hCaM+calcium channel CAV1.2<br />
 
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**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]] - hCaM+calcium channel CAV2.2<br />
 
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**[[5jth]], [[5jqa]] – hCaM + myosin light chain kinase peptide<br />
 
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**[[2k0f]], [[2lv6]] – hCaM+myosin light chain kinase peptide – NMR<br />
 
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**[[1zuz]] – hCaM+DRP kinase peptide<br />
 
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**[[1l7z]] – hCaM+CAP-23/NAP-22 CBD<br />
 
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**[[1cdl]] - hCaM+CaM dependent kinase CBD<br />
 
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**[[1iwq]] - hCaM+MARCKS CBD<br />
 
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**[[3sui]] – hCaM + capsaicin receptor peptide<br />
 
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**[[2m55]] – hCaM + α-synuclein peptide<br />
 
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**[[5nin]] – hCaM + A-kinase anchor peptide<br />
 
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**[[5j8h]] - hCaM + elongation factor 2 kinase CBD – NMR<br />
 
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**[[5dow]] - hCaM + chloride anion exchanger CBD <br />
 
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**[[2lgf]] – hCaM + selectin peptide<br />
 
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**[[2kn2]] – sCaM C-terminal+NtMKP1 CBD – NMR<br />
 
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**[[1cff]] - XlCaM+ calcium channel CBD - NMR<br />
 
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**[[1sy9]] – XlCaM+olfactory channel peptide<br />
 
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**[[1nwd]] – XlCaM+glutamate decarboxylase CBD<br />
 
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**[[1iq5]] – XlCaM+CaM dependent kinase CBD<br />
 
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**[[1ckk]] - XlCaM+CaM dependent kinase CBD - NMR<br />
 
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**[[2llo]], [[2llq]] – XlCaM EF-hand domain + estrogen receptor CBD – NMR<br />
 
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**[[5t0x]] - XlCaM + estrogen receptor CBD – NMR<br />
 
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**[[2mes]], [[5j7j]] – XlCaM +PSD95 peptide - NMR<br />
 
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**[[2mg5]] - XlCaM+nitric oxide synthase peptide - NMR<br />
 
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**[[2bbm]], [[2bbn]] - DmCaM+myosin light chain kinase peptide<br />
 
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**[[1mxe]] – DmCaM+rCaMKI CBD <br />
 
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**[[2fot]] - bCaM+α-II spectrin CBD<br />
 
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**[[2f2o]], [[2f2p]] – bCaM+calcium<br />
 
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**[[1xa5]] – bCaM+KAR-2<br />
 
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**[[1cm1]], [[1cm4]], [[1cdm]] - bCaM+CaM dependent kinase CBD<br />
 
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**[[4e50]] – mCam/linker/neurogranin IQ motif <br />
 
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**[[4e53]] – mCam/linker/neuromoduin IQ motif <br />
 
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**[[4aqr]] – AtCaM-7 + calcium-transporting ATPase peptide <br />
 
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**[[5k8q]] – faCaM + STRA6 peptide – fall armyworm<br />
 
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**[[2l1w]] – CaM + vacuolar calcium ATPase peptide – soybean – NMR<br />
 
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*Calmodulin complex with myosin
 
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**[[2vas]], [[2vb6]], [[3gn4]], [[3l9i]], [[4dbp]], [[4dbq]], [[2x51]], [[4anj]] – DmCaM + pMyosin IV<br />
 
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**[[4pjj]] - DmCaM + pMyosin VI<br />
 
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**[[3ek4]], [[3ek7]], [[3ek8]], [[3ekh]], [[3ekj]], [[3evr]], [[3evu]], [[3evv]], [[3o77]], [[3o78]] – CaM/DFP/myosin light chain kinase<br />
 
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**[[2dfs]] – cCaM + myosin 5A<br />
 
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**[[6bnv]] – cCaM + myosin 6 + actin<br />
 
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**[[4l79]], [[4byf]], [[5v7x]] – hCaM + myosin 1B<br />
 
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**[[6c1h]], [[6c1g]] – hCaM + myosin 1B + actin<br />
 
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**[[6c1d]] – hCaM + myosin 1B + actin + phalloidin<br />
 
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**[[5wsv]], [[5wsu]] – hCaM + myosin VII-A<br />
 
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**[[5i0i]] – hCaM + myosin X<br />
 
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**[[4zlk]] – mCaM + myosin VA<br />
 
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**[[4r8g]] – rCaM + myosin 1B<br />
 
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**[[2ix7]] – mCaM + myosin-5A<br />
 
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**[[2bki]], [[2bkh]] – pCaM + myosin VI – pig<br />
 
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*Calmodulin complex with ion channels
 
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**[[4djc]], [[2l53]], [[4ovn]] - hCaM + sodium channel protein type V α subunit<br />
 
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**[[4dck]], [[4jpz]] - hCaM + sodium channel protein type V α subunit + fibroblast growth factor 13<br />
 
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**[[4jq0]] - hCaM + sodium channel protein type V α subunit + fibroblast growth factor 12<br />
 
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**[[5k7l]] - hCaM + potassium channel EAG1 – Cryo EM <br />
 
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**[[5j03]], [[6feh]], [[6feg]], [[6b8q]], [[6b8p]], [[6b8n]], [[6b8m]], [[6b8l]], [[5vms]] - hCaM + potassium channel subfamily KQT <br />
 
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**[[5wc5]], [[5wbx]], [[5v03]], [[5v02]] – hCaM + potassium channel KCAT2.2 <br />
 
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*Calmodulin complex with other proteins
 
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**[[2col]], [[1yrt]], [[1yru]] – BpCaM +a denyl cyclase – ''Bordetella pertussis''<br />
 
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**[[1zot]] – BpCaM C-terminal+ adenyl cyclase<br />
 
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**[[1xfu]], [[1xfv]], [[1xfw]], [[1xfx]], [[1xfy]], [[1xfz]], [[1y0v]], [[1sk6]], [[1pk0]], [[1lvc]], [[1k90]], [[1k93]] - CaM + adenyl cyclase – ''Bacillus anthracis''<br />
 
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**[[3j41]] – hCaM + lens fiber major intrinsic protein – Cryo EM<br />
 
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**[[1qs7]], [[1qtx]] – EcCaM + RS20 – ''Escherichia coli''<br />
 
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**[[1vrk]] – EcCaM (mutant) + RS20<br />
 
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**[[4ds7]] – CaM + spindle pole body component 10 – ''Kluyveromyces lactis''<br />
 
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**[[2x0g]] – hCaM + death-associated protein kinase 1 (DAP)<br />
 
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**[[2k3s]] – XlCaM + smoothelin-like protein 1 – NMR<br />
 
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**[[4lzx]], [[4m1l]] - hCaM + IQ domain-containing protein G<br />
 
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**[[4q57]] – hCaM N-terminal + plectin<br />
 
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**[[4q5u]] – hCaM + calcineurin<br />
 
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**[[5sy1]] – faCaM + STRA6 <br />
 
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}}
 
==See Also==
==See Also==

Revision as of 08:45, 21 April 2019

Human calmodulin complex with ethanol and Ca+2 ions (green) (PDB code 1cll)

Drag the structure with the mouse to rotate

See Also

Bibliography

  1. ↑ Chattopadhyaya R, Meador WE, Means AR, Quiocho FA. Calmodulin structure refined at 1.7 A resolution. J Mol Biol. 1992 Dec 20;228(4):1177-92. PMID:1474585
  2. ↑ Bertini I, Giachetti A, Luchinat C, Parigi G, Petoukhov MV, Pierattelli R, Ravera E, Svergun DI. Conformational Space of Flexible Biological Macromolecules from Average Data. J Am Chem Soc. 2010 Sep 7. PMID:20822180 doi:10.1021/ja1063923
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