2iub
From Proteopedia
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| - | [[Image:2iub.gif|left|200px]]<br /> | + | [[Image:2iub.gif|left|200px]]<br /><applet load="2iub" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2iub" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2iub, resolution 2.90Å" /> | caption="2iub, resolution 2.90Å" /> | ||
'''CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.'''<br /> | '''CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IUB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with CL and MG as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2IUB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with CL and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Cl Binding Site For Chain G'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: membrane protein]] | [[Category: membrane protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:35:00 2007'' |
Revision as of 17:25, 18 December 2007
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CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.
Overview
CorA family members are ubiquitously distributed transporters of divalent, metal cations and are considered to be the primary Mg2+ transporter of, Bacteria and Archaea. We have determined a 2.9 angstrom resolution, structure of CorA from Thermotoga maritima that reveals a pentameric, cone-shaped protein. Two potential regulatory metal binding sites are, found in the N-terminal domain that bind both Mg2+ and Co2+. The structure, of CorA supports an efflux system involving dehydration and rehydration of, divalent metal ions potentially mediated by a ring of conserved aspartate, residues at the cytoplasmic entrance and a carbonyl funnel at the, periplasmic side of the pore.
About this Structure
2IUB is a Single protein structure of sequence from Thermotoga maritima with CL and MG as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution., Eshaghi S, Niegowski D, Kohl A, Martinez Molina D, Lesley SA, Nordlund P, Science. 2006 Jul 21;313(5785):354-7. PMID:16857941
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