4uci

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<StructureSection load='4uci' size='340' side='right'caption='[[4uci]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='4uci' size='340' side='right'caption='[[4uci]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hmpv Hmpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UCI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ucj|4ucj]], [[4uck|4uck]], [[4ucl|4ucl]], [[4ucy|4ucy]], [[4ucz|4ucz]], [[4ud0|4ud0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uci OCA], [https://pdbe.org/4uci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uci RCSB], [https://www.ebi.ac.uk/pdbsum/4uci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uci ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uci OCA], [http://pdbe.org/4uci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uci RCSB], [http://www.ebi.ac.uk/pdbsum/4uci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uci ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/L_HMPVC L_HMPVC]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
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[https://www.uniprot.org/uniprot/Q91L20_9MONO Q91L20_9MONO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hmpv]]
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[[Category: Human metapneumovirus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Canard, B]]
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[[Category: Canard B]]
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[[Category: Collet, A]]
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[[Category: Collet A]]
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[[Category: Debart, F]]
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[[Category: Debart F]]
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[[Category: Decroly, E]]
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[[Category: Decroly E]]
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[[Category: Grimes, J M]]
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[[Category: Grimes JM]]
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[[Category: Paesen, G C]]
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[[Category: Paesen GC]]
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[[Category: Sallamand, C]]
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[[Category: Sallamand C]]
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[[Category: Vasseur, J J]]
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[[Category: Vasseur JJ]]
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[[Category: Adenosine]]
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[[Category: Capping]]
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[[Category: Gtp]]
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[[Category: L protein]]
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[[Category: Methyltransferase]]
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[[Category: Rossmann]]
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[[Category: S-adenosyl methionine]]
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[[Category: Transferase]]
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[[Category: Triphosphatase]]
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Revision as of 08:15, 22 March 2023

X-ray structure and activities of an essential Mononegavirales L- protein domain

PDB ID 4uci

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