6c5r

<table><tr><td colspan='2'>[[6c5r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Metaq Metaq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5R FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAC_01752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=655827 METAQ])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5r OCA], [http://pdbe.org/6c5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5r RCSB], [http://www.ebi.ac.uk/pdbsum/6c5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5r ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called the mitochondrial calcium uniporter (MCU). Here, we determined the structures of the pore-forming MCU proteins from two fungi by X-ray crystallography and single-particle cryo-electron microscopy. The stoichiometry, overall architecture, and individual subunit structure differed markedly from those described in the recent nuclear magnetic resonance structure of Caenorhabditis elegans MCU. We observed a dimer-of-dimer architecture across species and chemical environments, which was corroborated by biochemical experiments. Structural analyses and functional characterization uncovered the roles of key residues in the pore. These results reveal a new ion channel architecture, provide insights into calcium coordination, selectivity and conduction, and establish a structural framework for understanding the mechanism of mitochondrial calcium uniporter function.

 

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== References ==

[[Category: Metaq]]

[[Category: Fan, C]]

[[Category: Fan, M]]

[[Category: Fastman, N]]

[[Category: Feng, L]]

[[Category: Zhang, J]]

[[Category: Cytosolic protein]]