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4qro

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<StructureSection load='4qro' size='340' side='right'caption='[[4qro]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4qro' size='340' side='right'caption='[[4qro]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qro]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Polsj Polsj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QRO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qro]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Polaromonas_sp._JS666 Polaromonas sp. JS666]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QRO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38L:2-NITROBENZENE-1,3-DIOL'>38L</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38L:2-NITROBENZENE-1,3-DIOL'>38L</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s4t|3s4t]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qro OCA], [https://pdbe.org/4qro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qro RCSB], [https://www.ebi.ac.uk/pdbsum/4qro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qro ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bpro_2061 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=296591 POLSJ])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qro OCA], [http://pdbe.org/4qro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qro RCSB], [http://www.ebi.ac.uk/pdbsum/4qro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qro ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRDC_POLSJ GRDC_POLSJ] Involved in the gamma-resorcylate (2,6-dihydroxybenzoate) catabolism (Probable). Catalyzes the reversible decarboxylation of gamma-resorcylate to resorcinol (PubMed:29283551). Also catalyzes the decarboxylation of 2,3-dihydroxybenzoate to catechol, 2,4,6-trihydroxybenzoate to benzene-1,3,5-triol, and 2,6-dihydroxy-4-methylbenzoate to 5-methylbenzene-1,3-diol (PubMed:29283551).<ref>PMID:29283551</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Polsj]]
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[[Category: Polaromonas sp. JS666]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Bhosle, R]]
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[[Category: Bhosle R]]
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[[Category: Gerlt, J A]]
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[[Category: Gerlt JA]]
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[[Category: Patskovsky, Y]]
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[[Category: Patskovsky Y]]
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[[Category: Raushel, M]]
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[[Category: Raushel M]]
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[[Category: Toro, R]]
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[[Category: Toro R]]
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[[Category: Vladimirova, A]]
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[[Category: Vladimirova A]]
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[[Category: Decarboxylase]]
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[[Category: Efi]]
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[[Category: Enzyme function initiative]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 13:49, 22 February 2023

CRYSTAL STRUCTURE of DIHYDROXYBENZOIC ACID DECARBBOXYLASE BPRO_2061 (TARGET EFI-500288) FROM POLAROMONAS SP. JS666 WITH BOUND MANGANESE AND AN INHIBITOR, 2-NITRORESORCINOL

PDB ID 4qro

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