4qr9

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<StructureSection load='4qr9' size='340' side='right'caption='[[4qr9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4qr9' size='340' side='right'caption='[[4qr9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qr9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QR9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qr9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QR9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hmgb1, Hmg-1, Hmg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr9 OCA], [https://pdbe.org/4qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/4qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr9 OCA], [http://pdbe.org/4qr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HMGB1_RAT HMGB1_RAT]] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
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[https://www.uniprot.org/uniprot/HMGB1_RAT HMGB1_RAT] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acosta-Reyes, F J]]
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[[Category: Rattus norvegicus]]
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[[Category: Campos, J L]]
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[[Category: Synthetic construct]]
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[[Category: Churchill, M E.A]]
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[[Category: Acosta-Reyes FJ]]
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[[Category: Malarkey, C S]]
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[[Category: Campos JL]]
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[[Category: Sanchez-Giraldo, R]]
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[[Category: Churchill MEA]]
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[[Category: Saperas, N]]
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[[Category: Malarkey CS]]
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[[Category: Architectural factor]]
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[[Category: Sanchez-Giraldo R]]
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[[Category: Bend dna]]
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[[Category: Saperas N]]
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[[Category: Box a domain]]
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[[Category: Chromatin]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: High mobility group]]
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[[Category: Hmg-box]]
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[[Category: Hmgb1]]
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[[Category: Kink dna]]
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[[Category: Minor groove]]
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[[Category: Nucleus]]
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Revision as of 13:48, 22 February 2023

Crystal structure of two HMGB1 Box A domains cooperating to underwind and kink a DNA

PDB ID 4qr9

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