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| | <StructureSection load='4qzu' size='340' side='right'caption='[[4qzu]], [[Resolution|resolution]] 1.50Å' scene=''> | | <StructureSection load='4qzu' size='340' side='right'caption='[[4qzu]], [[Resolution|resolution]] 1.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4qzu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qzu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rct|2rct]], [[2rcq|2rcq]], [[4eej|4eej]], [[4efg|4efg]], [[4ede|4ede]], [[4qzt|4qzt]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzu OCA], [https://pdbe.org/4qzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzu RCSB], [https://www.ebi.ac.uk/pdbsum/4qzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzu ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzu OCA], [http://pdbe.org/4qzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzu RCSB], [http://www.ebi.ac.uk/pdbsum/4qzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzu ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol. | + | [https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Retinol-binding protein|Retinol-binding protein]] | + | *[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Assar, Z]] | + | [[Category: Assar Z]] |
| - | [[Category: Geiger, J H]] | + | [[Category: Geiger JH]] |
| - | [[Category: Human cellular retinol binding protein ii]]
| + | |
| - | [[Category: Intracellular lipid binding protein]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| - | [[Category: Retinal]]
| + | |
| - | [[Category: Retinoid chaperone]]
| + | |
| - | [[Category: Retinol]]
| + | |
| - | [[Category: X-ray damage]]
| + | |
| - | [[Category: X-ray flux]]
| + | |
| Structural highlights
Function
RET2_HUMAN Intracellular transport of retinol.
Publication Abstract from PubMed
Cellular retinol-binding proteins (CRBPs) I and II, which are members of the intracellular lipid-binding protein (iLBP) family, are retinoid chaperones that are responsible for the intracellular transport and delivery of both retinol and retinal. Although structures of retinol-bound CRBPI and CRBPII are known, no structure of a retinal-bound CRBP has been reported. In addition, the retinol-bound human CRBPII (hCRBPII) structure shows partial occupancy of a noncanonical conformation of retinol in the binding pocket. Here, the structure of retinal-bound hCRBPII and the structure of retinol-bound hCRBPII with retinol fully occupying the binding pocket are reported. It is further shown that the retinoid derivative seen in both the zebrafish CRBP and the hCRBPII structures is likely to be the product of flux-dependent and wavelength-dependent X-ray damage during data collection. The structures of retinoid-bound CRBPs are compared and contrasted, and rationales for the differences in binding affinities for retinal and retinol are provided.
Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.,Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3226-32. doi:, 10.1107/S1399004714023839. Epub 2014 Nov 22. PMID:25478840[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J. Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3226-32. doi:, 10.1107/S1399004714023839. Epub 2014 Nov 22. PMID:25478840 doi:http://dx.doi.org/10.1107/S1399004714023839
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