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4qlp

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<StructureSection load='4qlp' size='340' side='right'caption='[[4qlp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='4qlp' size='340' side='right'caption='[[4qlp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qlp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QLP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qlp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QLP FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HKBT1_4117, Rv3902c, Rv3903c, RVBD_3902c, RVBD_3903c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), HKBT1_4118, Rv3902c, Rv3903c, RVBD_3902c, RVBD_3903c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qlp OCA], [https://pdbe.org/4qlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qlp RCSB], [https://www.ebi.ac.uk/pdbsum/4qlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qlp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qlp OCA], [http://pdbe.org/4qlp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qlp RCSB], [http://www.ebi.ac.uk/pdbsum/4qlp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qlp ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFTNT_MYCTU IFTNT_MYCTU] Antitoxin for tuberculosis necrotizing toxin (TNT). Acts by binding directly to TNT, which inhibits NAD(+) glycohydrolase activity of TNT and protects M.tuberculosis from self-poisoning.<ref>PMID:26237511</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Cingolani, G]]
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[[Category: Cingolani G]]
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[[Category: Doornbos, K S]]
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[[Category: Doornbos KS]]
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[[Category: Lokareddy, R K]]
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[[Category: Lokareddy RK]]
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[[Category: Niederweis, M]]
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[[Category: Niederweis M]]
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[[Category: Siroy, A]]
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[[Category: Siroy A]]
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[[Category: Speer, A]]
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[[Category: Speer A]]
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[[Category: Sun, J]]
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[[Category: Sun J]]
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[[Category: B-nad+ glycohydrolase]]
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[[Category: Duf4237]]
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[[Category: Factor rv3902c renamed here as immunity factor of tnt]]
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[[Category: Hydrolase-protein binding complex]]
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[[Category: Membrane]]
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[[Category: Nad-binding domain]]
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Revision as of 11:34, 15 February 2023

Atomic structure of tuberculosis necrotizing toxin (TNT) complexed with its immunity factor IFT

PDB ID 4qlp

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