|
|
| Line 3: |
Line 3: |
| | <StructureSection load='4qtq' size='340' side='right'caption='[[4qtq]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='4qtq' size='340' side='right'caption='[[4qtq]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4qtq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanac Xanac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qtq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_citri_pv._citri_str._306 Xanthomonas citri pv. citri str. 306]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QTQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XAC2610, Xanthomonas axonopodis pv. citri ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=190486 XANAC])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtq OCA], [https://pdbe.org/4qtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qtq RCSB], [https://www.ebi.ac.uk/pdbsum/4qtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qtq ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtq OCA], [http://pdbe.org/4qtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qtq RCSB], [http://www.ebi.ac.uk/pdbsum/4qtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qtq ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8PJC5_XANAC Q8PJC5_XANAC] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 22: |
Line 23: |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Xanac]] | + | [[Category: Xanthomonas citri pv. citri str. 306]] |
| - | [[Category: Farah, C S]] | + | [[Category: Farah CS]] |
| - | [[Category: Guzzo, C R]] | + | [[Category: Guzzo CR]] |
| - | [[Category: Souza, D P]] | + | [[Category: Souza DP]] |
| - | [[Category: Beta-propeller fragment]]
| + | |
| - | [[Category: Beta-sandwich]]
| + | |
| - | [[Category: Calcium binding motif]]
| + | |
| - | [[Category: Hydrolase inhibitor]]
| + | |
| - | [[Category: Immunity protein xanthomona]]
| + | |
| - | [[Category: Peptidoglycan hydrolase inhibitor]]
| + | |
| Structural highlights
Function
Q8PJC5_XANAC
Publication Abstract from PubMed
Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein-DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. Many bacteria of the family Xanthomonadaceae, which occupy diverse environmental niches, carry a T4SS with unknown function but with several characteristics that distinguishes it from other T4SSs. Here we show that the Xanthomonas citri T4SS provides these cells the capacity to kill other Gram-negative bacterial species in a contact-dependent manner. The secretion of one type IV bacterial effector protein is shown to require a conserved C-terminal domain and its bacteriolytic activity is neutralized by a cognate immunity protein whose 3D structure is similar to peptidoglycan hydrolase inhibitors. This is the first demonstration of the involvement of a T4SS in bacterial killing and points to this special class of T4SS as a mediator of both antagonistic and cooperative interbacterial interactions.
Bacterial killing via a type IV secretion system.,Souza DP, Oka GU, Alvarez-Martinez CE, Bisson-Filho AW, Dunger G, Hobeika L, Cavalcante NS, Alegria MC, Barbosa LR, Salinas RK, Guzzo CR, Farah CS Nat Commun. 2015 Mar 6;6:6453. doi: 10.1038/ncomms7453. PMID:25743609[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Souza DP, Oka GU, Alvarez-Martinez CE, Bisson-Filho AW, Dunger G, Hobeika L, Cavalcante NS, Alegria MC, Barbosa LR, Salinas RK, Guzzo CR, Farah CS. Bacterial killing via a type IV secretion system. Nat Commun. 2015 Mar 6;6:6453. doi: 10.1038/ncomms7453. PMID:25743609 doi:http://dx.doi.org/10.1038/ncomms7453
|
