Carboxypeptidase

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Revision as of 08:02, 25 April 2019

Pig carboxypeptidase B complex with acetate and Zn+2 ions (grey) (PDB code 3wc6)

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References

↑ Fernandez D, Boix E, Pallares I, Aviles FX, Vendrell J. Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A. Enzyme Res. 2011;2011:128676. doi: 10.4061/2011/128676. Epub 2011 Jul 25. PMID:21804935 doi:10.4061/2011/128676
↑ Adler M, Bryant J, Buckman B, Islam I, Larsen B, Finster S, Kent L, May K, Mohan R, Yuan S, Whitlow M. Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B. Biochemistry. 2005 Jul 5;44(26):9339-47. PMID:15982000 doi:http://dx.doi.org/10.1021/bi0501941
↑ Yoshimoto N, Itoh T, Inaba Y, Ishii H, Yamamoto K. Structural Basis for Inhibition of Carboxypeptidase B by Selenium-Containing Inhibitor: Selenium Coordinates to Zinc in Enzyme. J Med Chem. 2013 Sep 24. PMID:24010887 doi:10.1021/jm400816v

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Carboxypeptidase

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Revision as of 08:02, 25 April 2019

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3D Structures of Carboxypeptidase

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@@ Line 33: / Line 33: @@
 </StructureSection>
-== 3D Structures of Carboxypeptidase ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Carboxypeptidase A'''
-**[[5cpa]], [[1yme]], [[1cps]], [[1ee3]], [[1cpx]], [[1m4l]] – bCPA – bovine<br />
-**[[1arl]] – bCPA <br />
-**[[1arm]], [[1eel]], [[1ell]], [[1elm]] – bCPA Zn-substituted<br />
-**[[1k9x]] – PfCPA apo – ''Pyrococcus furiosus''<br />
-**[[1ka2]], [[1ka4]] - PfCPA Zn-substituted<br />
-**[[5wvu]], [[3hoa]] – CPA – ''Thermus thermophilus''<br />
-**[[2v77]] – hCPA1 – human<br />
-**[[3dwc]] – CPA – ''Trypanosoma cruzi''<br />
-**[[3g23]] – CPA – ''Novosphingobium aromaticivorans''<br />
-**[[4ox5]] – SpCPA – ''Stretomyces pneumoniae''<br />
-**[[5e3x]] – CPA – ''Fervidobacterium islandicum''<br />
-**[[5giv]] – CPA – ''Deinococcus radiodurans''<br />
-*''CPA complex with small molecules''
-**[[3cpa]] – bCPA + glycyl-tyrosine <br />
-**[[1f57]] – bCPA + cysteine<br />
-**[[1hdq]], [[1hdu]], [[1hee]] – bCPA + phenylalanine derivative<br />
-**[[6cpa]], [[7cpa]], [[8cpa]] – bCPA + phosphate derivative<br />
-**[[2scp]], [[1cbx]], [[1bav]], [[1iy7]], [[2rfh]], [[3fx6]], [[3fvl]], [[3hlp]], [[3huv]], [[3kgq]] – bCPA + inhibitor<br />
-**[[3i1u]] – bCPA + thiirane<br />
-**[[2ctb]], [[2ctc]] – bCPA + phenyl lactate<br />
-**[[2pcu]] – hCPA4 + peptide <br />
-**[[4uee]], [[4uef]], [[4uez]] – hCPA1 + peptide inhibitor<br />
-**[[4uf4]], [[5om9]], [[6i6z]] – hCPA1 + inhibitor<br />
-**[[4oxd]] – SpCP + peptidoglycan<br />
-*''CPA complex with protein''
-**[[1zlh]] – bCPA + tick inhibitor<br />
-**[[4cpa]] – bCPA + potato inhibitor<br />
-**[[2abz]] - bCPA + metallo-CP inhibitor<br />
-**[[3fju]] – hCPA1 + ascaris inhibitor<br />
-**[[1dtd]] – hCPA2 + metallo-CP inhibitor<br />
-**[[2bo9]] – hCPA4 hydrolase domain + latexin<br />
-**[[4bd9]] - hCPA4 hydrolase domain + SMCI inhibitor<br />
-**[[4a94]] – hCPA4 + nerita versicolor inhibitor<br />
-*'''Procarboxypeptidase A'''
-**[[1fon]] – bPCPA subunit III<br />
-**[[1pyt]] – bPCPA + proproteinase E + chymotrypsinogen C<br />
-**[[1jqg]] – PCPA – Cotton bollworm<br />
-**[[1aye]] – hPCPA2 <br />
-**[[1o6x]] – hPCPA2 activation domain – NMR<BR />
-**[[2boa]] – hPCPA4<br />
-*'''Carboxypeptidase B'''
-**[[1cpb]], [[3dgv]] – bCPB <br />
-**[[3d4u]], [[3osl]] – bCPB + CP inhibitor<br />
-**[[2c1c]] – CPB – Corn earworm<br />
-**[[3glj]] – pCPB residues 16-416 - pig<br />
-**[[5jc6]] – pCPB catalytic domain residues 111-416 <br />
-**[[3wab]], [[3wc5]], [[3wc6]], [[3wc7]], [[5lyf]], [[5lyi]], [[5lyl]], [[4z65]], [[4uia]], [[2piy]], [[2piz]], [[2pj0]], [[2pj1]], [[2pj2]], [[2pj3]], [[2pj4]], [[2pj5]], [[2pj6]], [[2pj7]], [[2pj8]], [[2pj9]], [[2pja]], [[2pjb]], [[2pjc]], [[5j1q]], [[5zeq]] – pCPB catalytic domain + inhibitor<br />
-**[[5lyd]], [[4uib]] – pCPB catalytic domain (mutant) + inhibitor<br />
-**[[5lrg]], [[5lrj]], [[5lrk]] – pCPB catalytic domain + anabaenopepsin peptide<br />
-**[[3d66]] – hCPB 2<br />
-**[[3d68]] – hCPB 2 (mutant)<br />
-**[[3lms]] – hCPB 2 + protein inhibitor<br />
-**[[5hvf]], [[5hvg]], [[5hvh]] – hCPB 2 (mutant) + nanobody inhibitor<br />
-**[[4p10]] – hCPB 2 (mutant) + inhibitor<br />
-**[[3d67]] – hCPB 2 + GEMSA<br />
-**[[1zli]] - hCPB + tick inhibitor<br />
-*'''Procarboxypeptidase B'''
-**[[1pba]] – pPCPB activation domain – NMR<BR />
-**[[1nsa]] – pPCPB<br />
-**[[1z5r]] - pPCPB catalytic domain<br />
-**[[1kwm]] - hPCPB<br />
-**[[1pca]] – pPCPB + valine<br />
-**[[1zg7]], [[1zg8]], [[1zg9]] – pPCPB + inhibitor<br />
-*'''Carboxypeptidase D'''
-**[[1qmu]] – dCPD domain II - duck <br />
-**[[1h8l]] - dCPD domain II + GEMSA<br />
-**[[3mn8]] – DmCPD + GEMSA – ''Drosophila melanogaster''<br />
-**[[5aq0]] – hCPD transthyretin-like domain<br />
-*'''Dipeptidyl carboxypeptidase I'''
-**[[2iul]], [[2iux]] – hCPI (mutant) <br />
-**[[2c6f]] – hCPI N domain<br />
-**[[2x8y]] – DmCPI <br />
-**[[5l43]] – AhCPI – ''Astrosporangium hypotensionis''<br />
-*''Dipeptidyl carboxypeptidase I complexes''
-**[[2x8z]], [[2x90]], [[2x91]], [[2x92]], [[2x93]], [[2x94]], [[2x95]], [[2x96]], [[2x97]] – DmCPI + anti-hypersensitive drug<br />
-**[[2xhm]] - DmCPI + phosphate derivative<br />
-**[[2oc2]], [[2xy9]], [[2xyd]] – hCPI + phosphate derivative<br />
-**[[3nxq]] - hCPI (mutant) + phosphate derivative<br />
-**[[3bkk]], [[3bkl]], [[3l3n]] – hCPI + inhibitor<br />
-**[[2ydm]], [[3zqz]] – hCPI + captopril derivative<br />
-**[[5l44]] – AhCPI + peptide inhibitor <br />
-*'''Carboxypeptidase L'''
-**[[1ivy]]– hCPL
-*'''Carboxypeptidase M'''
-**[[1uwy]] – hCPM
-*'''Carboxypeptidase N'''
-**[[2nsm]] – hCPN catalytic domain
-*'''Carboxypeptidase O'''
-**[[5mrv]] – hCPO + metallo-CP inhibitor<br />
-*'''Carboxypeptidase T'''
-**[[1obr]], [[3qnv]] – TvCPT – ''Thermoaclinomyces vulgaris''<br />
-**[[3prt]], [[3v38]], [[4ihm]] – TvCPT (mutant)<br />
-**[[4djl]], [[5myh]], [[6go2]] – TvCPT + sulfamoyl derivative<br />
-**[[4iav]], [[6q4l]], [[6f79]], [[6f75]], [[6f6q]] – TvCPT (mutant) + sulfamoyl derivative<br />
-**[[4duk]] – TvCPT + benzyl succinic acid<br />
-**[[4f8z]] – TvCPT + leucine derivative<br />
-**[[4ik2]] – TvCPT (mutant) + leucine derivative<br />
-**[[4gm5]] – TvCPT + arginine derivative<br />
-**[[3v7z]] – TvCPT + GEMSA<br />
-*'''Carboxypeptidase Y'''
-**[[1obr]], [[1wpx]] – yCPY + CPY inhibitor - yeast
-*'''Serine carboxypeptidase'''
-**[[3sc2]] – wSCP II – wheat<br />
-**[[1ysc]], [[1cpy]] – ySCP<br />
-**[[2j7v]] – SeSCP – ''Synechococcus elongatus''<br />
-**[[2j9o]] – SeSCP (mutant)
-*''Serine carboxypeptidase complexes''
-**[[1whs]], [[1wht]] - wSCP II + benzylsuccinate<br />
-**[[1bcr]], [[1bcs]] - wSCP II + antipain + arginine<br />
-**[[2j8y]] – SeSCP + penicillin<br />
-**[[2jbf]] - SeSCP (mutant) + penicillin
-*'''Arginine carboxypeptidase'''
-**[[3be7]], [[3dug]] – RCP<br />
-**[[3mtw]] – RCP + arginine derivative – ''Caulobacter vibrioides''
-*'''D-alanyl-D-alanine carboxypeptidase'''
-**[[1w79]], [[1w8q]] – AACP – ''Actinomadura''<br />
-**[[4rye]] – MtAACP <br />
-**[[5fsr]] – EcAACP <br />
-**[[3pte]], [[1skf]] – StAACP – ''Streptomyces''<br />
-**[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StAACP (mutant) <br />
-**[[1lbu]] – SaAACP + Zn – ''Streptomyces albus''<br />
-**[[6c39]] – AACP + Zn – ''Staphylococcus aureus''<br />
-**[[5zhf]] – EfAACP + Zn – ''Enterococcus faecalis''<br />
-**[[5hnm]] – EfAACP (mutant) + Zn <br />
-**[[6a6a]] – EfAACP + Zn + Ala <br />
-**[[5zhw]] – EfAACP + Zn + Ala-Ala<br />
-**[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcAACP  + antibiotic<br />
-**[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], **[[1pwg]] – StAACP + antibiotic<br />
-**[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]], [[4b4x]], [[4b4z]] – AcAACP + boronic acid derivative<br />
-**[[1ikg]], [[1iki]] – StAACP + peptidoglycan fragment<br />
-**[[1mpl]] - StAACP + phosphonate inhibitor<br />
-**[[1scw]], [[1sde]] - StAACP + cyclic phosphate inhibitor<br />
-**[[1yqs]] - StAACP + sultam inhibitor<br />
-**[[3zcz]] – AcAACP + inhibitor<br />
-**[[5j8x]] – EcAACP + inhibitor<br />
-**[[6ntz]] – EcAACP + meropenem<br />
-*β-lactamase/D-alanine carboxypeptidase
-**[[5evi]] - LACP – ''Pseudomonas syringae''<br />
-**[[3ozh]], [[3rju]] – ACP – ''Yersinia pestis''<br />
-*'''Glutamate carboxypeptidase II'''
-**[[1z8l]], [[2oot]] – hECP II<br />
-**[[2c6c]], [[2jbj]], [[2jbk]], [[2or4]], [[3d7d]], [[3d7f]], [[3d7g]], [[3d7h]], [[3iww]], [[3sjf]], [[4jyw]], [[4jz0]], [[4lqg]], [[5ely]], [[5d29]], [[4x3r]], [[4w9y]], [[6hkz]], [[6hkj]], [[6h7z]], [[6h7y]], [[6f5l]], [[6ety]] – hECP II + inhibitor<br />
-**[[6fe5]], [[6ez9]], [[5of0]] - hECP II (mutant) + inhibitor<br />
-**[[4p44]], [[4p45]], [[4p4e]], [[4p4d]], [[4p4f]], [[4p4i]], [[4p4j]], [[4p4b]]  – hECP II + phosphoramidate inhibitor<br />
-**[[4ngm]], [[4ngn]], [[4ngp]], [[4ngq]], [[4ngr]], [[4ngs]], [[4ngt]], [[4oc0]], [[4oc1]], [[4oc2]], [[4oc3]], [[4oc4]], [[4oc5]], [[4ome]], [[5o5u]], [[5o5t]], [[5o5r]] - hECP II + urea derivative<br />
-**[[2c6g]] - hECP II + glutamate<br />
-**[[4mcr]], [[4mcs]] - hECP II (mutant) + glutamate<br />
-**[[4mcp]], [[4mcq]], [[5f09]] - hECP II (mutant) + glutamate derivative<br />
-**[[3bhx]], [[3bi0]], [[3bi1]] - hECP II + transition state analog<br />
-**[[2cij]] – hECP II + methionine<br />
-**[[2pvv]] - hECP II + serine-sulfate<br />
-**[[2c6p]], [[2pvw]] - hECP II + phosphate derivative<br />
-**[[3rbu]] – hECP II + PMPA<br />
-**[[3bxm]] – hECP II (mutant) + dipeptide<br />
-**[[3sje]], [[3sjg]], [[3sjx]] - hECP II (mutant) + inhibitor<br />
-**[[2xef]], [[2xeg]], [[2xei]], [[2xej]] – hECP II + antibody-recruiting molecule<br />
-**[[1cg2]] – ECP II – ''Pseudomonas''
-*'''Glutamate carboxypeptidase III'''
-**[[3fec]] – hECP III<br />
-**[[3fed]] - hECP III + transition state analog<br />
-**[[3fee]] – hECP III + inhibitor<br />
-**[[3ff3]] - hECP III + glutamate
-*'''Prolyl carboxypeptidase'''
-**[[3n2z]] - hPCP
-*'''Angiotensin-converting enzyme-related carboxypeptidase'''
-See [[Angiotensin-Converting Enzyme]]
-*'''M32 carboxypeptidase'''
-**[[3hq2]] – BsCP
-*'''Muramoyl pentapeptide carboxypeptidase'''
-**[[1lbu]] – SaCP<br />
-*'''Metallo-carboxypeptidase'''
-**[[4a37]] – PaCP – ''Pseudomonas aeruginosa''<br />
-**[[4a38]] – PaCP + benzyl succinic acid<br />
-**[[4a39]] – PaCP + GEMSA<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]